Looking to the horizon: the role of bilirubin in the development and prevention of age-related chronic diseases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295098" target="_blank" >RIV/00216208:11110/15:10295098 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/15:10295098

Výsledek na webu

<a href="http://www.clinsci.org/content/129/1/1" target="_blank" >http://www.clinsci.org/content/129/1/1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1042/CS20140566" target="_blank" >10.1042/CS20140566</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Looking to the horizon: the role of bilirubin in the development and prevention of age-related chronic diseases

Popis výsledku v původním jazyce

Bilirubin, the principal tetrapyrrole, bile pigment and catabolite of haem, is an emerging biomarker of disease resistance, which may be related to several recently documented biological functions. Initially believed to be toxic in infants, the perception of bilirubin has undergone a transformation: it is now considered to be a molecule that may promote health in adults. Data from the last decade demonstrate that mildly elevated serum bilirubin levels are strongly associated with reduced prevalence of chronic diseases, particularly cardiovascular diseases (CVDs), as well as CVD-related mortality and risk factors. Recent data also link bilirubin to other chronic diseases, including cancer and Type 2 diabetes mellitus, and to all-cause mortality. Therefore, there is evidence to suggest that bilirubin is a biomarker for reduced chronic disease prevalence and a predictor of all-cause mortality, which is of important clinical significance. In the present review, detailed information on the

Název v anglickém jazyce

Looking to the horizon: the role of bilirubin in the development and prevention of age-related chronic diseases

Popis výsledku anglicky

Bilirubin, the principal tetrapyrrole, bile pigment and catabolite of haem, is an emerging biomarker of disease resistance, which may be related to several recently documented biological functions. Initially believed to be toxic in infants, the perception of bilirubin has undergone a transformation: it is now considered to be a molecule that may promote health in adults. Data from the last decade demonstrate that mildly elevated serum bilirubin levels are strongly associated with reduced prevalence of chronic diseases, particularly cardiovascular diseases (CVDs), as well as CVD-related mortality and risk factors. Recent data also link bilirubin to other chronic diseases, including cancer and Type 2 diabetes mellitus, and to all-cause mortality. Therefore, there is evidence to suggest that bilirubin is a biomarker for reduced chronic disease prevalence and a predictor of all-cause mortality, which is of important clinical significance. In the present review, detailed information on the

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

—

Projekt

<a href="/cs/project/LH11030" target="_blank" >LH11030: Studium potenciálních antiproliferativních účinků jedlých řas</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Science

ISSN

0143-5221

e-ISSN

—

Svazek periodika

129

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

25

Strana od-do

1-25

Kód UT WoS článku

000353226500001

EID výsledku v databázi Scopus

2-s2.0-84937511631