Vitamin D Binding Protein Is Not Involved in Vitamin D Deficiency in Patients with Chronic Kidney Disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295121" target="_blank" >RIV/00216208:11110/15:10295121 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/15:10295121 RIV/00064165:_____/15:10295121

Výsledek na webu

<a href="http://dx.doi.org/10.1155/2015/492365" target="_blank" >http://dx.doi.org/10.1155/2015/492365</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2015/492365" target="_blank" >10.1155/2015/492365</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Vitamin D Binding Protein Is Not Involved in Vitamin D Deficiency in Patients with Chronic Kidney Disease

Popis výsledku v původním jazyce

Objective. This study was designed to evaluate vitamin D status with separate determination of 25-OH D-2 and 25-OH D-3 and its relationship to vitamin D binding protein (VDBP) in patients with chronic kidney disease (CKD) and long-term haemodialysis patients (HD). Methods. 45 CKD patients, 103 HD patients, and 25 controls (C) were included. Plasma vitamin D concentrations were determined using chromatography and VDBP in serum and urine in CKD using enzyme immunoassay. Results. Plasma vitamin D levels were lower in CKD (30.16 +/- 16.74 ng/mL) and HD(18.85 +/- 15.85 ng/mL) versus C(48.72 +/- 18.35 ng/mL), P < 0.0001. 25-OH D-3 was the dominant form of vitamin D. Serum VDBP was higher in CKD (273.2 +/- 93.8 ug/mL) versus C (222 +/- 87.6 ug/mL) and HD (213.8 +/- 70.9 ug/mL), P = 0.0003. Vitamin D/VDBP ratio was the highest in C and the lowest in HD; however, there was no correlation between vitamin D and VDBP. Urinary concentration of VDBP in CKD (0.25 +/- 0.13 ug/mL) correlated with prote

Název v anglickém jazyce

Vitamin D Binding Protein Is Not Involved in Vitamin D Deficiency in Patients with Chronic Kidney Disease

Popis výsledku anglicky

Objective. This study was designed to evaluate vitamin D status with separate determination of 25-OH D-2 and 25-OH D-3 and its relationship to vitamin D binding protein (VDBP) in patients with chronic kidney disease (CKD) and long-term haemodialysis patients (HD). Methods. 45 CKD patients, 103 HD patients, and 25 controls (C) were included. Plasma vitamin D concentrations were determined using chromatography and VDBP in serum and urine in CKD using enzyme immunoassay. Results. Plasma vitamin D levels were lower in CKD (30.16 +/- 16.74 ng/mL) and HD(18.85 +/- 15.85 ng/mL) versus C(48.72 +/- 18.35 ng/mL), P < 0.0001. 25-OH D-3 was the dominant form of vitamin D. Serum VDBP was higher in CKD (273.2 +/- 93.8 ug/mL) versus C (222 +/- 87.6 ug/mL) and HD (213.8 +/- 70.9 ug/mL), P = 0.0003. Vitamin D/VDBP ratio was the highest in C and the lowest in HD; however, there was no correlation between vitamin D and VDBP. Urinary concentration of VDBP in CKD (0.25 +/- 0.13 ug/mL) correlated with prote

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BioMed Research International

ISSN

2314-6133

e-ISSN

—

Svazek periodika

Neuveden

Číslo periodika v rámci svazku

January

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

—

Kód UT WoS článku

000354683500001

EID výsledku v databázi Scopus

2-s2.0-84929631170