Early magnetic resonance imaging predictors of clinical progression after 48months in clinically isolated syndrome patients treated with intramuscular interferon beta-1a

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295612" target="_blank" >RIV/00216208:11110/15:10295612 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/15:10295612

Výsledek na webu

<a href="http://dx.doi.org/10.1111/ene.12716" target="_blank" >http://dx.doi.org/10.1111/ene.12716</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ene.12716" target="_blank" >10.1111/ene.12716</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Early magnetic resonance imaging predictors of clinical progression after 48months in clinically isolated syndrome patients treated with intramuscular interferon beta-1a

Popis výsledku v původním jazyce

Background and purposeOur aim was to identify early imaging surrogate markers of clinical progression in patients after the first demyelinating event suggestive of multiple sclerosis treated with weekly intramuscular interferon -1a. In a prospective observational study, the predictive role of baseline and 6-month changes in magnetic resonance imaging outcomes was investigated with respect to relapse activity and development of confirmed disability progression in patients after 48months. MethodsThis study examined 210 patients. Multivariate Cox proportional hazard models were used to analyse predictors of relapse activity and confirmed disability progression after 48months. ResultsGreater T2 lesion volume [hazard ratio (HR) 1.81; P=0.005] and the presence of contrast-enhancing lesions (HR 2.13; P<0.001) at baseline were significantly associated with increased cumulative risk of a second clinical attack over 48months. A greater decrease of the corpus callosum volume (HR 2.74; P=0.001) an

Název v anglickém jazyce

Early magnetic resonance imaging predictors of clinical progression after 48months in clinically isolated syndrome patients treated with intramuscular interferon beta-1a

Popis výsledku anglicky

Background and purposeOur aim was to identify early imaging surrogate markers of clinical progression in patients after the first demyelinating event suggestive of multiple sclerosis treated with weekly intramuscular interferon -1a. In a prospective observational study, the predictive role of baseline and 6-month changes in magnetic resonance imaging outcomes was investigated with respect to relapse activity and development of confirmed disability progression in patients after 48months. MethodsThis study examined 210 patients. Multivariate Cox proportional hazard models were used to analyse predictors of relapse activity and confirmed disability progression after 48months. ResultsGreater T2 lesion volume [hazard ratio (HR) 1.81; P=0.005] and the presence of contrast-enhancing lesions (HR 2.13; P<0.001) at baseline were significantly associated with increased cumulative risk of a second clinical attack over 48months. A greater decrease of the corpus callosum volume (HR 2.74; P=0.001) an

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

<a href="/cs/project/NT13237" target="_blank" >NT13237: Klinické a paraklinické markery roztroušené sklerózy – korelace se současným stavem pacienta a predikce průběhu nemoci.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Neurology

ISSN

1351-5101

e-ISSN

—

Svazek periodika

22

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

1113-1123

Kód UT WoS článku

000356090800014

EID výsledku v databázi Scopus

2-s2.0-84930758628