The neurotoxicity of iron, copper and manganese in Parkinson's and Wilson's diseases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295613" target="_blank" >RIV/00216208:11110/15:10295613 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/15:10295613

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jtemb.2014.05.007" target="_blank" >http://dx.doi.org/10.1016/j.jtemb.2014.05.007</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jtemb.2014.05.007" target="_blank" >10.1016/j.jtemb.2014.05.007</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The neurotoxicity of iron, copper and manganese in Parkinson's and Wilson's diseases

Popis výsledku v původním jazyce

Impaired cellular homeostasis of metals, particularly of Cu, Fe and Mn may trigger neurodegeneration through various mechanisms, notably induction of oxidative stress, promotion of a-synuclein aggregation and fibril formation, activation of microglial cells leading to inflammation and impaired production of metalloproteins. In this article we review available studies concerning Fe, Cu and Mn in Parkinson's disease and Wilson's disease. In Parkinson's disease local dysregulation of iron metabolism in thesubstantia nigra (SN) seems to be related to neurodegeneration with an increase in SN iron concentration, accompanied by decreased SN Cu and ceruloplasmin concentrations and increased free Cu concentrations and decreased ferroxidase activity in the cerebrospinal fluid. Available data in Wilson's disease suggest that substantial increases in CNS Cu concentrations persist for a long time during chelating treatment and that local accumulation of Fe in certain brain nuclei may occur during

Název v anglickém jazyce

The neurotoxicity of iron, copper and manganese in Parkinson's and Wilson's diseases

Popis výsledku anglicky

Impaired cellular homeostasis of metals, particularly of Cu, Fe and Mn may trigger neurodegeneration through various mechanisms, notably induction of oxidative stress, promotion of a-synuclein aggregation and fibril formation, activation of microglial cells leading to inflammation and impaired production of metalloproteins. In this article we review available studies concerning Fe, Cu and Mn in Parkinson's disease and Wilson's disease. In Parkinson's disease local dysregulation of iron metabolism in thesubstantia nigra (SN) seems to be related to neurodegeneration with an increase in SN iron concentration, accompanied by decreased SN Cu and ceruloplasmin concentrations and increased free Cu concentrations and decreased ferroxidase activity in the cerebrospinal fluid. Available data in Wilson's disease suggest that substantial increases in CNS Cu concentrations persist for a long time during chelating treatment and that local accumulation of Fe in certain brain nuclei may occur during

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

<a href="/cs/project/7F14308" target="_blank" >7F14308: Srovnávací studie Huntingtonovy choroby pomocí biochemických, imunocytochemických a molekulárně genetických metod na tkáních myši, miniprasete a člověka</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Trace Elements in Medicine and Biology

ISSN

0946-672X

e-ISSN

—

Svazek periodika

31

Číslo periodika v rámci svazku

July

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

11

Strana od-do

193-203

Kód UT WoS článku

000356192400031

EID výsledku v databázi Scopus

2-s2.0-84929654685