The brighter (and evolutionarily older) face of the metabolic syndrome: evidence from Trypanosoma cruzi infection in CD-1 mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295793" target="_blank" >RIV/00216208:11110/15:10295793 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/15:10295793

Výsledek na webu

<a href="http://dx.doi.org/10.1002/dmrr.2636" target="_blank" >http://dx.doi.org/10.1002/dmrr.2636</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/dmrr.2636" target="_blank" >10.1002/dmrr.2636</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The brighter (and evolutionarily older) face of the metabolic syndrome: evidence from Trypanosoma cruzi infection in CD-1 mice

Popis výsledku v původním jazyce

BackgroundInfection with Trypanosoma cruzi, the protozoan parasite that causes Chagas disease, results in chronic infection that leads to cardiomyopathy with increased mortality and morbidity in endemic regions. In a companion study, our group found thata high-fat diet (HFD) protected mice from T.cruzi-induced myocardial damage and significantly reduced post-infection mortality during acute T.cruzi infection. MethodsIn the present study metabolic syndrome was induced prior to T. cruzi infection by feeding a high fat diet. Also, mice were treated with anti-diabetic drug metformin. ResultsIn the present study, the lethality of T.cruzi (Brazil strain) infection in CD-1 mice was reduced from 55% to 20% by an 8-week pre-feeding of an HFD to induce obesityand metabolic syndrome. The addition of metformin reduced mortality to 3%. ConclusionsIt is an interesting observation that both the high fat diet and the metformin, which are known to differentially attenuate host metabolism, effectively

Název v anglickém jazyce

The brighter (and evolutionarily older) face of the metabolic syndrome: evidence from Trypanosoma cruzi infection in CD-1 mice

Popis výsledku anglicky

BackgroundInfection with Trypanosoma cruzi, the protozoan parasite that causes Chagas disease, results in chronic infection that leads to cardiomyopathy with increased mortality and morbidity in endemic regions. In a companion study, our group found thata high-fat diet (HFD) protected mice from T.cruzi-induced myocardial damage and significantly reduced post-infection mortality during acute T.cruzi infection. MethodsIn the present study metabolic syndrome was induced prior to T. cruzi infection by feeding a high fat diet. Also, mice were treated with anti-diabetic drug metformin. ResultsIn the present study, the lethality of T.cruzi (Brazil strain) infection in CD-1 mice was reduced from 55% to 20% by an 8-week pre-feeding of an HFD to induce obesityand metabolic syndrome. The addition of metformin reduced mortality to 3%. ConclusionsIt is an interesting observation that both the high fat diet and the metformin, which are known to differentially attenuate host metabolism, effectively

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

—

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Diabetes/Metabolism Research and Reviews [online]

ISSN

1520-7560

e-ISSN

—

Svazek periodika

31

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

346-359

Kód UT WoS článku

000353396700004

EID výsledku v databázi Scopus

2-s2.0-84928209062