Trefoil factor family (TFF) proteins as potential serum biomarkers in patients with metastatic colorectal cancer
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295802" target="_blank" >RIV/00216208:11110/15:10295802 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/61383082:_____/15:#0000396 RIV/00216208:11130/15:10295802 RIV/00064165:_____/15:10295802
Výsledek na webu
<a href="http://dx.doi.org/10.4149/neo_2015_056" target="_blank" >http://dx.doi.org/10.4149/neo_2015_056</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/neo_2015_056" target="_blank" >10.4149/neo_2015_056</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Trefoil factor family (TFF) proteins as potential serum biomarkers in patients with metastatic colorectal cancer
Popis výsledku v původním jazyce
Trefoil factor family (TFF) is composed of three secretory proteins (TFF1, TFF2 and TFF3) that play an important role in mucosal protection of gastrointestinal tract. Their overexpression in colorectal tumors seems to be associated with more aggressive disease. We collected serum samples from 79 healthy controls and 97 patients with metastatic colorectal cancer at the time of diagnosis or at progression. Serum levels of TTF1-3, CEA and CA19-9 were measured by ELISA. Serum TFF I and TFF3 levels were significantly higher in patients with colorectal cancer compared to healthy controls (p < 0.0001). Moreover, serum levels of TFF3 correlated with extent of liver involvement in patient without pulmonary metastases and patients with higher TFF3 levels had significantly worse outcome (p < 0.0001). Compared to CEA and CA19-9, TFF3 had higher sensitivity and the same specificity Our results indicate that TFF3 is an effective biomarker in patients with metastatic colorectal cancer with higher sen
Název v anglickém jazyce
Trefoil factor family (TFF) proteins as potential serum biomarkers in patients with metastatic colorectal cancer
Popis výsledku anglicky
Trefoil factor family (TFF) is composed of three secretory proteins (TFF1, TFF2 and TFF3) that play an important role in mucosal protection of gastrointestinal tract. Their overexpression in colorectal tumors seems to be associated with more aggressive disease. We collected serum samples from 79 healthy controls and 97 patients with metastatic colorectal cancer at the time of diagnosis or at progression. Serum levels of TTF1-3, CEA and CA19-9 were measured by ELISA. Serum TFF I and TFF3 levels were significantly higher in patients with colorectal cancer compared to healthy controls (p < 0.0001). Moreover, serum levels of TFF3 correlated with extent of liver involvement in patient without pulmonary metastases and patients with higher TFF3 levels had significantly worse outcome (p < 0.0001). Compared to CEA and CA19-9, TFF3 had higher sensitivity and the same specificity Our results indicate that TFF3 is an effective biomarker in patients with metastatic colorectal cancer with higher sen
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FD - Onkologie a hematologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Neoplasma
ISSN
0028-2685
e-ISSN
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Svazek periodika
62
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
SK - Slovenská republika
Počet stran výsledku
8
Strana od-do
470-477
Kód UT WoS článku
000357705300016
EID výsledku v databázi Scopus
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