Magnetic Resonance Phase Alterations in Multiple Sclerosis Patients with Short and Long Disease Duration

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10296092" target="_blank" >RIV/00216208:11110/15:10296092 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/15:10296092

Výsledek na webu

<a href="http://dx.doi.org/10.1371/journal.pone.0128386" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0128386</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0128386" target="_blank" >10.1371/journal.pone.0128386</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Magnetic Resonance Phase Alterations in Multiple Sclerosis Patients with Short and Long Disease Duration

Popis výsledku v původním jazyce

Objective The analysis of the MR phase provides additional information on the tissue microstructure. In multiple sclerosis (MS) lesions phase alterations may reflect different stages of inflammatory activity. Here we investigated lesion morphology in MSpatients with short and long disease duration on T2* weighted, phase, magnitude and susceptibility weighted imaging (SWI) at 7 Tesla (T). Methods 17 MS or clinically isolated syndrome patients with short (<60 months) and 11 with long (>60 months) diseaseduration underwent 7T MRI. Lesions were subsequently analyzed side-by-side with regard to morphology and visibility on T2* weighted, SWI, magnitude and SWI-filtered phase images. Results 126 of 192 T2* weighted lesions (65.6%) were characterized by a phase alteration pattern, and hence could be differentiated on phase images. In detail, a significantly reduced proportion of lesions showing phase alterations was detectable in patients with longer disease duration (mean +/- SD 51 +/- 37%,

Název v anglickém jazyce

Magnetic Resonance Phase Alterations in Multiple Sclerosis Patients with Short and Long Disease Duration

Popis výsledku anglicky

Objective The analysis of the MR phase provides additional information on the tissue microstructure. In multiple sclerosis (MS) lesions phase alterations may reflect different stages of inflammatory activity. Here we investigated lesion morphology in MSpatients with short and long disease duration on T2* weighted, phase, magnitude and susceptibility weighted imaging (SWI) at 7 Tesla (T). Methods 17 MS or clinically isolated syndrome patients with short (<60 months) and 11 with long (>60 months) diseaseduration underwent 7T MRI. Lesions were subsequently analyzed side-by-side with regard to morphology and visibility on T2* weighted, SWI, magnitude and SWI-filtered phase images. Results 126 of 192 T2* weighted lesions (65.6%) were characterized by a phase alteration pattern, and hence could be differentiated on phase images. In detail, a significantly reduced proportion of lesions showing phase alterations was detectable in patients with longer disease duration (mean +/- SD 51 +/- 37%,

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PLoS ONE

ISSN

1932-6203

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

—

Kód UT WoS článku

000358198700003

EID výsledku v databázi Scopus

2-s2.0-84940185620