Atypical Polypoid Adenomyoma of the Uterus An Immunohistochemical and Molecular Study of 21 Cases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10296269" target="_blank" >RIV/00216208:11110/15:10296269 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/15:10296269 RIV/00216208:11150/15:10296269 RIV/00179906:_____/15:10296269 RIV/00064203:_____/15:10296269 RIV/00064165:_____/15:10296269

Výsledek na webu

<a href="http://dx.doi.org/10.1097/PAS.0000000000000428" target="_blank" >http://dx.doi.org/10.1097/PAS.0000000000000428</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/PAS.0000000000000428" target="_blank" >10.1097/PAS.0000000000000428</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Atypical Polypoid Adenomyoma of the Uterus An Immunohistochemical and Molecular Study of 21 Cases

Popis výsledku v původním jazyce

Atypical polypoid adenomyoma (APA) is an uncommon uterine lesion that commonly recurs after local excision and is occasionally associated with or precedes the development of atypical hyperplasia or endometrioid adenocarcinoma. Despite the fact that about230 cases have been reported in the literature, only 2 studies of 6 and of 7 cases have investigated the molecular aspects; as such, molecular alterations that occur in APA remain largely unknown. We undertook a comprehensive immunohistochemical and molecular analysis of 21 cases of APA in 17 patients (including 4 recurrent/persistent lesions). The analyzed genes were PTEN and TP53 (by fluorescence in situ hybridization) and KRAS, BRAF, EGFR, and NRAS (all by polymerase chain reaction). Immunohistochemical staining was performed for PTEN, p53, mTOR, -catenin, HNF-1, and GLUT1 and for the mismatch-repair proteins MLH-1, MSH-2, MSH-6, and PMS-2. In most cases, there was nuclear expression of -catenin in squamous morules and expression of

Název v anglickém jazyce

Atypical Polypoid Adenomyoma of the Uterus An Immunohistochemical and Molecular Study of 21 Cases

Popis výsledku anglicky

Atypical polypoid adenomyoma (APA) is an uncommon uterine lesion that commonly recurs after local excision and is occasionally associated with or precedes the development of atypical hyperplasia or endometrioid adenocarcinoma. Despite the fact that about230 cases have been reported in the literature, only 2 studies of 6 and of 7 cases have investigated the molecular aspects; as such, molecular alterations that occur in APA remain largely unknown. We undertook a comprehensive immunohistochemical and molecular analysis of 21 cases of APA in 17 patients (including 4 recurrent/persistent lesions). The analyzed genes were PTEN and TP53 (by fluorescence in situ hybridization) and KRAS, BRAF, EGFR, and NRAS (all by polymerase chain reaction). Immunohistochemical staining was performed for PTEN, p53, mTOR, -catenin, HNF-1, and GLUT1 and for the mismatch-repair proteins MLH-1, MSH-2, MSH-6, and PMS-2. In most cases, there was nuclear expression of -catenin in squamous morules and expression of

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Surgical Pathology

ISSN

0147-5185

e-ISSN

—

Svazek periodika

39

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

1148-1155

Kód UT WoS článku

000358417800016

EID výsledku v databázi Scopus

2-s2.0-84938078306