IL-1 receptor blockade alleviates endotoxin-mediated impairment of renal drug excretory functions in rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10296775" target="_blank" >RIV/00216208:11110/15:10296775 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/15:10296775 RIV/00216208:11160/15:10296775

Výsledek na webu

<a href="http://ajprenal.physiology.org/content/308/5/F388.full" target="_blank" >http://ajprenal.physiology.org/content/308/5/F388.full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1152/ajprenal.00266.2014" target="_blank" >10.1152/ajprenal.00266.2014</a>

Jazyk výsledku

angličtina

Název v původním jazyce

IL-1 receptor blockade alleviates endotoxin-mediated impairment of renal drug excretory functions in rats

Popis výsledku v původním jazyce

The aim of our study was to investigate whether two potent anti-inflammatory agents, dexamethasone and anakinra, an IL-1 receptor antagonist, may influence acute kidney injury (AKI) and associated drug excretory functions during endotoxemia (LPS) in rats. Ten hours after LPS administration, untreated endotoxemic rats developed typical symptoms of AKI, with reduced GFR, impaired tubular excretion of urea and sodium, and decreased urinary excretion of azithromycin, an anionic substrate for multidrug resistance-transporting proteins. Administration of both immunosuppressants attenuated the inflammatory response, liver damage, AKI, and increased renal clearance of azithromycin mainly by restoration of GFR, without significant influence on its tubular secretion. The lack of such an effect was related to the differential effect of both agents on the renal expression of individual drug transporters. Only dexamethasone increased the urinary clearance of bile acids, in accordance with the reduc

Název v anglickém jazyce

IL-1 receptor blockade alleviates endotoxin-mediated impairment of renal drug excretory functions in rats

Popis výsledku anglicky

The aim of our study was to investigate whether two potent anti-inflammatory agents, dexamethasone and anakinra, an IL-1 receptor antagonist, may influence acute kidney injury (AKI) and associated drug excretory functions during endotoxemia (LPS) in rats. Ten hours after LPS administration, untreated endotoxemic rats developed typical symptoms of AKI, with reduced GFR, impaired tubular excretion of urea and sodium, and decreased urinary excretion of azithromycin, an anionic substrate for multidrug resistance-transporting proteins. Administration of both immunosuppressants attenuated the inflammatory response, liver damage, AKI, and increased renal clearance of azithromycin mainly by restoration of GFR, without significant influence on its tubular secretion. The lack of such an effect was related to the differential effect of both agents on the renal expression of individual drug transporters. Only dexamethasone increased the urinary clearance of bile acids, in accordance with the reduc

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/EE2.3.30.0061" target="_blank" >EE2.3.30.0061: Zvýšení kapacity vědecko-výzkumných týmů Univerzity Karlovy prostřednictvím nových pozic pro absolventy doktorandských studií</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Physiology - Renal Physiology

ISSN

1931-857X

e-ISSN

—

Svazek periodika

308

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

"F388"-"F399"

Kód UT WoS článku

000350811800002

EID výsledku v databázi Scopus

2-s2.0-84924075862