TERT gene harbors multiple variants associated with pancreatic cancer susceptibility

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10297787" target="_blank" >RIV/00216208:11110/15:10297787 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/15:00451984 RIV/75010330:_____/15:00010918 RIV/00216208:11130/15:10297787 RIV/61989592:15110/15:33157158 RIV/61383082:_____/15:#0000395

Výsledek na webu

<a href="http://dx.doi.org/10.1002/ijc.29590" target="_blank" >http://dx.doi.org/10.1002/ijc.29590</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ijc.29590" target="_blank" >10.1002/ijc.29590</a>

Jazyk výsledku

angličtina

Název v původním jazyce

TERT gene harbors multiple variants associated with pancreatic cancer susceptibility

Popis výsledku v původním jazyce

A small number of common susceptibility loci have been identified for pancreatic cancer, one of which is marked by rs401681 in the TERT-CLPTM1L gene region on chromosome 5p15.33. Because this region is characterized by low linkage disequilibrium, we sought to identify whether additional single nucleotide polymorphisms (SNPs) could be related to pancreatic cancer risk, independently of rs401681. We performed an in-depth analysis of genetic variability of the telomerase reverse transcriptase (TERT) and the telomerase RNA component (TERC) genes, in 5,550 subjects with pancreatic cancer and 7,585 controls from the PANcreatic Disease ReseArch (PANDoRA) and the PanScan consortia. We identified a significant association between a variant in TERT and pancreatic cancer risk (rs2853677, odds ratio = 0.85; 95% confidence interval = 0.80-0.90, p = 8.3 x 10MINUS SIGN 8). Additional analysis adjusting rs2853677 for rs401681 indicated that the two SNPs are independently associated with pancreatic can

Název v anglickém jazyce

TERT gene harbors multiple variants associated with pancreatic cancer susceptibility

Popis výsledku anglicky

A small number of common susceptibility loci have been identified for pancreatic cancer, one of which is marked by rs401681 in the TERT-CLPTM1L gene region on chromosome 5p15.33. Because this region is characterized by low linkage disequilibrium, we sought to identify whether additional single nucleotide polymorphisms (SNPs) could be related to pancreatic cancer risk, independently of rs401681. We performed an in-depth analysis of genetic variability of the telomerase reverse transcriptase (TERT) and the telomerase RNA component (TERC) genes, in 5,550 subjects with pancreatic cancer and 7,585 controls from the PANcreatic Disease ReseArch (PANDoRA) and the PanScan consortia. We identified a significant association between a variant in TERT and pancreatic cancer risk (rs2853677, odds ratio = 0.85; 95% confidence interval = 0.80-0.90, p = 8.3 x 10MINUS SIGN 8). Additional analysis adjusting rs2853677 for rs401681 indicated that the two SNPs are independently associated with pancreatic can

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Cancer

ISSN

0020-7136

e-ISSN

—

Svazek periodika

137

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

9

Strana od-do

2175-2183

Kód UT WoS článku

000359782700016

EID výsledku v databázi Scopus

2-s2.0-84939251389