Intraindividual changes of dipeptidyl peptidase-IV in peripheral blood of patients with rheumatoid arthritis are associated with the disease activity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10297905" target="_blank" >RIV/00216208:11110/15:10297905 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023728:_____/15:#0005043

Výsledek na webu

<a href="http://dx.doi.org/10.1186/s12891-015-0707-y" target="_blank" >http://dx.doi.org/10.1186/s12891-015-0707-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12891-015-0707-y" target="_blank" >10.1186/s12891-015-0707-y</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Intraindividual changes of dipeptidyl peptidase-IV in peripheral blood of patients with rheumatoid arthritis are associated with the disease activity

Popis výsledku v původním jazyce

Background: Dipeptidyl peptidase-IV (DPP-IV) is suggested to contribute to the pathogenesis of several autoimmune diseases. The aim of this study was to evaluate the association of DPP-IV presence in blood plasma and mononuclear cells with the disease activity in rheumatoid arthritis (RA). Methods: Patients with active RA (n = 27) were examined at the study enrolment and a follow-up examination was performed after the regression of the joint effusions and at least 6 months after the first investigation.The control group comprised patients with a noninflammatory joint disease, i.e. osteoarthritis (OA; n = 15). The DPP-IV-like enzymatic activity was measured by a kinetic fluorimetric method, the concentration of DPP-IV in the blood plasma was determinedusing ELISA and the expression of DPP-IV in leukocytes was assayed by flow cytometry. Conclusions: The association between RA activity and the changes in blood plasma and blood mononuclear cell DPP-IV in individual patients supports the

Název v anglickém jazyce

Intraindividual changes of dipeptidyl peptidase-IV in peripheral blood of patients with rheumatoid arthritis are associated with the disease activity

Popis výsledku anglicky

Background: Dipeptidyl peptidase-IV (DPP-IV) is suggested to contribute to the pathogenesis of several autoimmune diseases. The aim of this study was to evaluate the association of DPP-IV presence in blood plasma and mononuclear cells with the disease activity in rheumatoid arthritis (RA). Methods: Patients with active RA (n = 27) were examined at the study enrolment and a follow-up examination was performed after the regression of the joint effusions and at least 6 months after the first investigation.The control group comprised patients with a noninflammatory joint disease, i.e. osteoarthritis (OA; n = 15). The DPP-IV-like enzymatic activity was measured by a kinetic fluorimetric method, the concentration of DPP-IV in the blood plasma was determinedusing ELISA and the expression of DPP-IV in leukocytes was assayed by flow cytometry. Conclusions: The association between RA activity and the changes in blood plasma and blood mononuclear cell DPP-IV in individual patients supports the

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

—

Projekt

<a href="/cs/project/NR9273" target="_blank" >NR9273: Význam molekul "DASH systému" v lokálních a systémových patogenetických procesech revmatoidní artritidy</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BMC Musculoskeletal Disorders

ISSN

1471-2474

e-ISSN

—

Svazek periodika

16

Číslo periodika v rámci svazku

September

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

—

Kód UT WoS článku

000360877300001

EID výsledku v databázi Scopus

2-s2.0-84941361082