Protective associations of HDL with blood-brain barrier injury in multiple sclerosis patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10301839" target="_blank" >RIV/00216208:11110/15:10301839 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/15:10301839

Výsledek na webu

<a href="http://dx.doi.org/10.1194/jlr.M060970" target="_blank" >http://dx.doi.org/10.1194/jlr.M060970</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1194/jlr.M060970" target="_blank" >10.1194/jlr.M060970</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Protective associations of HDL with blood-brain barrier injury in multiple sclerosis patients

Popis výsledku v původním jazyce

The purpose of this work was to investigate the associations of serum cholesterol and apolipoproteins with measures of blood-brain barrier (BBB) permeability and CNS inflammation following the first clinical demyelinating event. This study included 154 patients [67% female; age, 29.5 +/- 8.2 years (mean +/- SD)] enrolled in a multi-center study of interferon 1-a treatment following the first demyelinating event. Blood and cerebrospinal fluid (CSF) were obtained at screening prior to treatment. A comprehensive serum lipid profile and multiple surrogate markers of BBB breakdown and CNS immune activity were obtained. Higher levels of serum HDL cholesterol (HDL-C) and ApoA-I were associated with lower CSF total protein level, CSF albumin level, albumin quotient, and CSF IgG level (all P 0.001 for HDL-C and all P < 0.01 for ApoA-I). HDL-C was also associated with CSF CD80+ (P < 0.001) and with CSF CD80+CD19+ (P = 0.007) cell frequencies. Higher serum HDL is associated with lower levels of B

Název v anglickém jazyce

Protective associations of HDL with blood-brain barrier injury in multiple sclerosis patients

Popis výsledku anglicky

The purpose of this work was to investigate the associations of serum cholesterol and apolipoproteins with measures of blood-brain barrier (BBB) permeability and CNS inflammation following the first clinical demyelinating event. This study included 154 patients [67% female; age, 29.5 +/- 8.2 years (mean +/- SD)] enrolled in a multi-center study of interferon 1-a treatment following the first demyelinating event. Blood and cerebrospinal fluid (CSF) were obtained at screening prior to treatment. A comprehensive serum lipid profile and multiple surrogate markers of BBB breakdown and CNS immune activity were obtained. Higher levels of serum HDL cholesterol (HDL-C) and ApoA-I were associated with lower CSF total protein level, CSF albumin level, albumin quotient, and CSF IgG level (all P 0.001 for HDL-C and all P < 0.01 for ApoA-I). HDL-C was also associated with CSF CD80+ (P < 0.001) and with CSF CD80+CD19+ (P = 0.007) cell frequencies. Higher serum HDL is associated with lower levels of B

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Lipid Research

ISSN

0022-2275

e-ISSN

—

Svazek periodika

56

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

2010-2018

Kód UT WoS článku

000361846300015

EID výsledku v databázi Scopus

2-s2.0-84946605829