Hepatic triacylglycerol composition in experimental model of non-alcoholic steatohepatitis

Kód výsledku v IS VaVaI

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Nalezeny alternativní kódy

RIV/00064165:_____/15:10312757

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Hepatic triacylglycerol composition in experimental model of non-alcoholic steatohepatitis

Popis výsledku v původním jazyce

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) probably represent the most common chronic liver diseases in western countries with a substantial risk of liver cirrhosis and high cardiovascular morbidity and mortality.The pathogenic mechanism involved in the development of fatty liver remains unclear. It is known that severity of steatosis is well correlated with progression to NASH in humans, and several recent reports gave suggested that accumulation of lipids in the liver, and especially disturbances in the composition of hepatic fatty acids, might play a causal role in the development of NASH. Intricacies of the molecular and cellular mechanisms responsible for progression from simple steatosis to NASH have not been fully elucidated. Excessive accumulation of lipid substrates in the liver has serious adverse effects on cell functions and especially saturated free fatty acids are directly hepatotoxic, perhaps by mediating an endoplasmic reticulum

Název v anglickém jazyce

Hepatic triacylglycerol composition in experimental model of non-alcoholic steatohepatitis

Popis výsledku anglicky

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) probably represent the most common chronic liver diseases in western countries with a substantial risk of liver cirrhosis and high cardiovascular morbidity and mortality.The pathogenic mechanism involved in the development of fatty liver remains unclear. It is known that severity of steatosis is well correlated with progression to NASH in humans, and several recent reports gave suggested that accumulation of lipids in the liver, and especially disturbances in the composition of hepatic fatty acids, might play a causal role in the development of NASH. Intricacies of the molecular and cellular mechanisms responsible for progression from simple steatosis to NASH have not been fully elucidated. Excessive accumulation of lipid substrates in the liver has serious adverse effects on cell functions and especially saturated free fatty acids are directly hepatotoxic, perhaps by mediating an endoplasmic reticulum

Druh

D - Stať ve sborníku

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Atherosklerosa 2015

ISBN

978-80-905595-2-3

ISSN

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e-ISSN

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Počet stran výsledku

2

Strana od-do

57-58

Název nakladatele

IV. interní klinika 1. LF UK

Místo vydání

Praha

Místo konání akce

Praha

Datum konání akce

9. 9. 2015

Typ akce podle státní příslušnosti

CST - Celostátní akce

Kód UT WoS článku

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