Effects of hypertonic saline and mannitol on cortical cerebral microcirculation in a rabbit craniotomy model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10313457" target="_blank" >RIV/00216208:11110/15:10313457 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/15:43875390 RIV/00216208:11150/15:10313457 RIV/00179906:_____/15:10313457

Výsledek na webu

<a href="http://dx.doi.org/10.1186/s12871-015-0067-z" target="_blank" >http://dx.doi.org/10.1186/s12871-015-0067-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12871-015-0067-z" target="_blank" >10.1186/s12871-015-0067-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of hypertonic saline and mannitol on cortical cerebral microcirculation in a rabbit craniotomy model

Popis výsledku v původním jazyce

Background: Hyperosmolar solutions have been used in neurosurgery to modify brain bulk and prevent neurological deterioration. The aim of this animal study was to compare the short-term effects of equivolemic, equiosmolar solutions of mannitol and hypertonic saline (HTS) on cerebral cortical microcirculation in a rabbit craniotomy model. Methods: Rabbits (weight, 2.0-3.0 kg) were anesthetized, ventilated mechanically, and subjected to a craniotomy. The animals were allocated randomly to receive a 3.75 ml/kg intravenous infusion of either 3.2 % HTS (group HTS, n = 8) or 20 % mannitol (group MTL, n = 8). Microcirculation in the cerebral cortex was evaluated using sidestream dark-field (SDF) imaging before and 20 min after the end of the 15-min HTS infusion. Global hemodynamic data were recorded, and blood samples for laboratory analysis were obtained at the time of SDF image recording. Results: No differences in the microcirculatory parameters were observed between the groups before the

Název v anglickém jazyce

Effects of hypertonic saline and mannitol on cortical cerebral microcirculation in a rabbit craniotomy model

Popis výsledku anglicky

Background: Hyperosmolar solutions have been used in neurosurgery to modify brain bulk and prevent neurological deterioration. The aim of this animal study was to compare the short-term effects of equivolemic, equiosmolar solutions of mannitol and hypertonic saline (HTS) on cerebral cortical microcirculation in a rabbit craniotomy model. Methods: Rabbits (weight, 2.0-3.0 kg) were anesthetized, ventilated mechanically, and subjected to a craniotomy. The animals were allocated randomly to receive a 3.75 ml/kg intravenous infusion of either 3.2 % HTS (group HTS, n = 8) or 20 % mannitol (group MTL, n = 8). Microcirculation in the cerebral cortex was evaluated using sidestream dark-field (SDF) imaging before and 20 min after the end of the 15-min HTS infusion. Global hemodynamic data were recorded, and blood samples for laboratory analysis were obtained at the time of SDF image recording. Results: No differences in the microcirculatory parameters were observed between the groups before the

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FJ - Chirurgie včetně transplantologie

OECD FORD obor

—

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BMC Anesthesiology

ISSN

1471-2253

e-ISSN

—

Svazek periodika

15

Číslo periodika v rámci svazku

June

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

—

Kód UT WoS článku

000355967100001

EID výsledku v databázi Scopus

2-s2.0-84931070112