Antidepressants substantially affect basic REM sleep characteristics in narcolepsy-cataplexy patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10319865" target="_blank" >RIV/00216208:11110/15:10319865 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023752:_____/15:43914881 RIV/00064165:_____/15:10319865

Výsledek na webu

<a href="http://www.nel.edu/archive_issues/o/36_5/36_5_Buskova--Sonka_430-433.pdf" target="_blank" >http://www.nel.edu/archive_issues/o/36_5/36_5_Buskova--Sonka_430-433.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Antidepressants substantially affect basic REM sleep characteristics in narcolepsy-cataplexy patients

Popis výsledku v původním jazyce

OBJECTIVES: Antidepressants substantially affect REM sleep characteristics and trigger manifestations of REM sleep behavior disorder (RBD) in the general, non-narcoleptic, population. Antidepressants are also frequently administrated in an attempt to suppress cataplexy. We investigated the role of antidepressants in the development of RBD in narcolepsy with cataplexy (NC) patients. PATIENTS/METHODS: Seventy-five patients diagnosed with NC were assessed by a structured interview (focused on RBD manifestations and the use of antidepressants) and night video-polysomnography followed by the multiple sleep latency test. RESULTS: Of all 75 NC patients (36 male, 39 female; mean age 46.1 +/- 18.5 years), 34 cases had a history of antidepressant use (45.3%; 18male, 16 female). In this antidepressant-positive group, 13 patients suffered from RBD (38.2%). Among antidepressant-naive patients, only 5 subjects (12.2%) were diagnosed with RBD. Polysomnographic data showed significantly increased REM

Název v anglickém jazyce

Antidepressants substantially affect basic REM sleep characteristics in narcolepsy-cataplexy patients

Popis výsledku anglicky

OBJECTIVES: Antidepressants substantially affect REM sleep characteristics and trigger manifestations of REM sleep behavior disorder (RBD) in the general, non-narcoleptic, population. Antidepressants are also frequently administrated in an attempt to suppress cataplexy. We investigated the role of antidepressants in the development of RBD in narcolepsy with cataplexy (NC) patients. PATIENTS/METHODS: Seventy-five patients diagnosed with NC were assessed by a structured interview (focused on RBD manifestations and the use of antidepressants) and night video-polysomnography followed by the multiple sleep latency test. RESULTS: Of all 75 NC patients (36 male, 39 female; mean age 46.1 +/- 18.5 years), 34 cases had a history of antidepressant use (45.3%; 18male, 16 female). In this antidepressant-positive group, 13 patients suffered from RBD (38.2%). Among antidepressant-naive patients, only 5 subjects (12.2%) were diagnosed with RBD. Polysomnographic data showed significantly increased REM

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Svazek periodika

36

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

SE - Švédské království

Počet stran výsledku

4

Strana od-do

430-433

Kód UT WoS článku

000368824900007

EID výsledku v databázi Scopus

2-s2.0-84959310197