Insights into the regulation of survivin expression in tumors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F16%3A10326983" target="_blank" >RIV/00216208:11110/16:10326983 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.omicsgroup.org/journals/insights-into-the-regulation-of-survivin-expression-in-tumors-2168-9431-1000139.pdf" target="_blank" >http://www.omicsgroup.org/journals/insights-into-the-regulation-of-survivin-expression-in-tumors-2168-9431-1000139.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4172/2168-9431.1000139" target="_blank" >10.4172/2168-9431.1000139</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Insights into the regulation of survivin expression in tumors

Popis výsledku v původním jazyce

Survivin is a member of the IAP (inhibitor of apoptosis) gene family and is markedly overexpressed exclusively in cancers but not in normal adult tissues [1-7] implying that it could be an ideal target for cancer directed therapy. Strong expression of survivin in tumors correlates with a poor cancer treatment response and poor outcomes. Notably, survivin is also present in some nonmalignant cells such as myeloid stem cells and peripheral blood mononuclear cells, T lymphocytes [6], melanocytes [8] and in hyperplastic polyps and sessile serrated adenomas [9]. Furthermore, survivin is widely expressed during embryogenesis in many tissues like human fetal lungs, liver, heart, kidney and gastrointestinal tract [5]. Apart from its role in antiapoptosis, survivin also plays a critical role in regulating the cell cycle at mitosis. To prevent apoptosis, survivin interacts with many regulatory factors [10]. Survivin is a small protein (displaying approximately 16.5-kDa band on SDS electrophoresis) and contains a single baculovirus IAP repeat but no RING finger motif, found in other IAP protein members. It is generally thought that transcriptional deregulation is a major mechanism involved in the aberrant expression of survivin in cancers. Transcription of the survivin gene proceeds from a single promoter but 5 splicing isoforms arise from the primary transcript [3]. The common survivin isoform contains 4 exons and isoform ΔEx3 (lacking exon 3) interacts with 4-exon survivin in the mitochondria where they inhibit mitochondrial-dependent apoptosis. Other survivin splice variants also colocalize with survivin in the mitochondria [3].

Název v anglickém jazyce

Insights into the regulation of survivin expression in tumors

Popis výsledku anglicky

Survivin is a member of the IAP (inhibitor of apoptosis) gene family and is markedly overexpressed exclusively in cancers but not in normal adult tissues [1-7] implying that it could be an ideal target for cancer directed therapy. Strong expression of survivin in tumors correlates with a poor cancer treatment response and poor outcomes. Notably, survivin is also present in some nonmalignant cells such as myeloid stem cells and peripheral blood mononuclear cells, T lymphocytes [6], melanocytes [8] and in hyperplastic polyps and sessile serrated adenomas [9]. Furthermore, survivin is widely expressed during embryogenesis in many tissues like human fetal lungs, liver, heart, kidney and gastrointestinal tract [5]. Apart from its role in antiapoptosis, survivin also plays a critical role in regulating the cell cycle at mitosis. To prevent apoptosis, survivin interacts with many regulatory factors [10]. Survivin is a small protein (displaying approximately 16.5-kDa band on SDS electrophoresis) and contains a single baculovirus IAP repeat but no RING finger motif, found in other IAP protein members. It is generally thought that transcriptional deregulation is a major mechanism involved in the aberrant expression of survivin in cancers. Transcription of the survivin gene proceeds from a single promoter but 5 splicing isoforms arise from the primary transcript [3]. The common survivin isoform contains 4 exons and isoform ΔEx3 (lacking exon 3) interacts with 4-exon survivin in the mitochondria where they inhibit mitochondrial-dependent apoptosis. Other survivin splice variants also colocalize with survivin in the mitochondria [3].

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

30204 - Oncology

Projekt

<a href="/cs/project/NT14005" target="_blank" >NT14005: Signální cesta Hedgehog-GLI: ukazatel biologického chování nádoru u melanomu, plicních a některých dalších nádorů, a její blokování jako protinádorová terapie.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Single Cell Biology [online]

ISSN

2168-9431

e-ISSN

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Svazek periodika

5

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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