Comprehensive serial study of dynamic remodeling of atherosclerotic coronary arteries using IVUS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F16%3A10327331" target="_blank" >RIV/00216208:11110/16:10327331 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1117/12.2217152" target="_blank" >http://dx.doi.org/10.1117/12.2217152</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1117/12.2217152" target="_blank" >10.1117/12.2217152</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comprehensive serial study of dynamic remodeling of atherosclerotic coronary arteries using IVUS

Popis výsledku v původním jazyce

We present a semi-automated approach to comprehensively examine coronary remodeling over the entire length of intravascular ultrasound (IVUS) imaged vessels. Serial measurements at baseline and 12-month follow-up are analyzed rather than static data obtained at a single time point. Every IVUS pullback is segmented automatically, and then reviewed and algorithmically refined by an expert using a computer-aided just-enough-interaction approach. Subsequently, pairs of serial IVUS pullbacks are registered automatically using 3D graph optimization approach. Based on plaque volume increases or decreases over time, pullback frames are divided into two groups - progression and regression. It is shown that plaque progression rates are positively correlated with percent stenosis (PS) indices (p << 0.01) while plaque regression rates are negatively correlated with percent stenosis indices (p << 0.01). Moreover, for the progression group, adventitia area increases in direct relation with the baseline percent stenosis (p=0.007) when PS is less than 50%. Significance of such a correlation is not observed when percent stenosis exceeds 50%. Conversely, for the regression group, change of adventitia area is relatively constant for percent stenosis <50%; but decreases in direct relation with baseline stenosis (p << 0.01) when stenosis > 50%. This strongly suggests that lipid lowering treatment may effectively suppress plaque progression and accelerate plaque regression, especially for larger values of percent stenosis, and further accelerate the corresponding adventitia-remodeling process.

Název v anglickém jazyce

Comprehensive serial study of dynamic remodeling of atherosclerotic coronary arteries using IVUS

Popis výsledku anglicky

We present a semi-automated approach to comprehensively examine coronary remodeling over the entire length of intravascular ultrasound (IVUS) imaged vessels. Serial measurements at baseline and 12-month follow-up are analyzed rather than static data obtained at a single time point. Every IVUS pullback is segmented automatically, and then reviewed and algorithmically refined by an expert using a computer-aided just-enough-interaction approach. Subsequently, pairs of serial IVUS pullbacks are registered automatically using 3D graph optimization approach. Based on plaque volume increases or decreases over time, pullback frames are divided into two groups - progression and regression. It is shown that plaque progression rates are positively correlated with percent stenosis (PS) indices (p << 0.01) while plaque regression rates are negatively correlated with percent stenosis indices (p << 0.01). Moreover, for the progression group, adventitia area increases in direct relation with the baseline percent stenosis (p=0.007) when PS is less than 50%. Significance of such a correlation is not observed when percent stenosis exceeds 50%. Conversely, for the regression group, change of adventitia area is relatively constant for percent stenosis <50%; but decreases in direct relation with baseline stenosis (p << 0.01) when stenosis > 50%. This strongly suggests that lipid lowering treatment may effectively suppress plaque progression and accelerate plaque regression, especially for larger values of percent stenosis, and further accelerate the corresponding adventitia-remodeling process.

Druh

D - Stať ve sborníku

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging

ISBN

978-1-5106-0023-2

ISSN

0277-786X

e-ISSN

—

Počet stran výsledku

6

Strana od-do

—

Název nakladatele

SPIE

Místo vydání

San Diego

Místo konání akce

San Diego

Datum konání akce

1. 3. 2016

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000378223800030