Benzodiazepines, Age-Related Pharmacological Changes, and Risk of Falls in Older Adults

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F16%3A10336688" target="_blank" >RIV/00216208:11110/16:10336688 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11160/16:10336688

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/B9780128006344000330" target="_blank" >http://www.sciencedirect.com/science/article/pii/B9780128006344000330</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-12-800634-4.00033-0" target="_blank" >10.1016/B978-0-12-800634-4.00033-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Benzodiazepines, Age-Related Pharmacological Changes, and Risk of Falls in Older Adults

Popis výsledku v původním jazyce

Benzodiazepines belong to the group of hypnosedative medications. They are commonly prescribed for anxiety disorders and sleep problems and are widely used in younger adults as well as in the older population. However, their pharmacological profile can be influenced by age-related changes in pharmacokinetics and pharmacodynamics resulting in an increased potential to cause adverse effects such as daily sleepiness, fatigue, falls, cognitive impairment, and confusion. Falls in older people are described as multifactorial adverse events, with use of particular medications being one of the potential risk factors. Despite extensive evaluation of benzodiazepines' contribution to falls in older patients, the research yielded mixed results, and differences between particular drugs or dosage regimens remain questionable. Risk/benefit ratios of particular active substances in the group of benzodiazepines, their cautious indication for specific problems and rational selection, particularly in older adults with various multiple comorbidities, should be carefully evaluated in daily clinical practice.

Název v anglickém jazyce

Benzodiazepines, Age-Related Pharmacological Changes, and Risk of Falls in Older Adults

Popis výsledku anglicky

Benzodiazepines belong to the group of hypnosedative medications. They are commonly prescribed for anxiety disorders and sleep problems and are widely used in younger adults as well as in the older population. However, their pharmacological profile can be influenced by age-related changes in pharmacokinetics and pharmacodynamics resulting in an increased potential to cause adverse effects such as daily sleepiness, fatigue, falls, cognitive impairment, and confusion. Falls in older people are described as multifactorial adverse events, with use of particular medications being one of the potential risk factors. Despite extensive evaluation of benzodiazepines' contribution to falls in older patients, the research yielded mixed results, and differences between particular drugs or dosage regimens remain questionable. Risk/benefit ratios of particular active substances in the group of benzodiazepines, their cautious indication for specific problems and rational selection, particularly in older adults with various multiple comorbidities, should be carefully evaluated in daily clinical practice.

Druh

C - Kapitola v odborné knize

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Neuropathology of Drug Addictions and Substance Misuse: Volume 3

ISBN

978-0-12-800634-4

Počet stran výsledku

11

Strana od-do

334-344

Počet stran knihy

1106

Název nakladatele

Elsevier

Místo vydání

Amsterdam

Kód UT WoS kapitoly

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