Long-Term Effect of Adrenalectomy on Cardiovascular Remodeling in Patients With Pheochromocytoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10333494" target="_blank" >RIV/00216208:11110/17:10333494 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/17:00075957 RIV/00064165:_____/17:10333494

Výsledek na webu

<a href="http://dx.doi.org/10.1210/jc.2016-2422" target="_blank" >http://dx.doi.org/10.1210/jc.2016-2422</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1210/jc.2016-2422" target="_blank" >10.1210/jc.2016-2422</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Long-Term Effect of Adrenalectomy on Cardiovascular Remodeling in Patients With Pheochromocytoma

Popis výsledku v původním jazyce

Catecholamines may contribute to the accumulation of collagen fibers and extracellular matrix in the arterial and myocardial wall due to various mechanisms. Reversibility of this process has not been studied on both structures simultaneously. OBJECTIVE: This study aimed to clarify the long-term effect of catecholamines&apos; excess normalization on carotid and myocardial wall changes in patients with pheochromocytoma or functional paraganglioma (PHEO) after tumor removal. Design, Settings and Patients: Carotid intima-media thickness (IMT) and left ventricle (LV) mass index were studied in 50 patients with PHEO before tumor removal and 5 years after tumor removal and in 50 blood pressure- and age-matched essential hypertensive patients (EH) before follow-up and after 5 years of follow-up. MAIN OUTCOME MEASURES: Common carotid IMT (CCA-IMT) and LV mass indexed to the lean body mass (LBM). RESULTS: Elimination of catecholamine excess in the PHEO group resulted in a significant decrease in CCA-IMT and LV mass index from 0.86 +- 0.17 to 0.83 +- 0.18 mm (P &lt;0.05) and from 3.2 +- 0.9 to 2.9 +- 0.9 g/LBM (P &lt;0.001), respectively. In contrast, CCA-IMT and LV mass index increased significantly from 0.78 +- 0.14 to 0.81 +- 0.15 mm (P &lt;0.05) and from 3.1 +- 0.7 to 3.2 +- 0.6 g/LBM (P &lt;0.05), respectively, in patients with essential hypertension. CONCLUSION: In patients with PHEO, carotid IMT and LV mass index can significantly regress after the tumor removal, in contrast to the impairment of these parameters in patients with EH during the same long-term period.

Název v anglickém jazyce

Long-Term Effect of Adrenalectomy on Cardiovascular Remodeling in Patients With Pheochromocytoma

Popis výsledku anglicky

Catecholamines may contribute to the accumulation of collagen fibers and extracellular matrix in the arterial and myocardial wall due to various mechanisms. Reversibility of this process has not been studied on both structures simultaneously. OBJECTIVE: This study aimed to clarify the long-term effect of catecholamines&apos; excess normalization on carotid and myocardial wall changes in patients with pheochromocytoma or functional paraganglioma (PHEO) after tumor removal. Design, Settings and Patients: Carotid intima-media thickness (IMT) and left ventricle (LV) mass index were studied in 50 patients with PHEO before tumor removal and 5 years after tumor removal and in 50 blood pressure- and age-matched essential hypertensive patients (EH) before follow-up and after 5 years of follow-up. MAIN OUTCOME MEASURES: Common carotid IMT (CCA-IMT) and LV mass indexed to the lean body mass (LBM). RESULTS: Elimination of catecholamine excess in the PHEO group resulted in a significant decrease in CCA-IMT and LV mass index from 0.86 +- 0.17 to 0.83 +- 0.18 mm (P &lt;0.05) and from 3.2 +- 0.9 to 2.9 +- 0.9 g/LBM (P &lt;0.001), respectively. In contrast, CCA-IMT and LV mass index increased significantly from 0.78 +- 0.14 to 0.81 +- 0.15 mm (P &lt;0.05) and from 3.1 +- 0.7 to 3.2 +- 0.6 g/LBM (P &lt;0.05), respectively, in patients with essential hypertension. CONCLUSION: In patients with PHEO, carotid IMT and LV mass index can significantly regress after the tumor removal, in contrast to the impairment of these parameters in patients with EH during the same long-term period.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

<a href="/cs/project/NV16-30345A" target="_blank" >NV16-30345A: Feochromocytom jako model chronické aktivace stresové osy v patogenezi metabolických poruch</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

The Journal of Clinical Endocrinology &amp; Metabolism

ISSN

0021-972X

e-ISSN

—

Svazek periodika

102

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

1208-1217

Kód UT WoS článku

000402195300013

EID výsledku v databázi Scopus

2-s2.0-85017285300