Immunonutrition in patients with cyctic fibrosis leads to drop of serum amyloid A and increase of oxidative stress

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10360586" target="_blank" >RIV/00216208:11110/17:10360586 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/17:10360586 RIV/00064203:_____/17:10360586

Výsledek na webu

<a href="https://www.jstage.jst.go.jp/article/jcbn/60/3/60_16-83/_article" target="_blank" >https://www.jstage.jst.go.jp/article/jcbn/60/3/60_16-83/_article</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3164/jcbn.16-83" target="_blank" >10.3164/jcbn.16-83</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Immunonutrition in patients with cyctic fibrosis leads to drop of serum amyloid A and increase of oxidative stress

Popis výsledku v původním jazyce

The aim of the present study is to evaluate of the impact of immunonutrition on parameters of oxidative stress and inflammation in patients with cystic fibrosis and malnutrition. In the 30 patients with cystic fibrosis and long-term enteral nutrition support for malnutrition the effect of standard and immunonutrion sipping on oxidative stress and inflammatory activity parameters was compared. Malonyldialdehyde (MDA) as parameter of oxidative stress and serum amyloid A (SAA), interleukin 1 and 6, hsCRP, IgM, IgA, IgG as parameters of inflammatory activity were examined. Immunonutrition decreased SAA to 17.6 mg/L comparing to 25.6 mg/L when standard nutrition was given (p = 0.014). MDA was 0.66 mu M on standard and 0.96 mu M on immunonutrition support (p &lt; 0.01). The significant negative correlation was recorded between MDA and SAA, hs-CRP, interleukin 6, IgA and IgG. In conclusion, the application of immunonutrition in patients with cystic fibrosis and malnutrition is associated with drop of SAA but with the rise of MDA.

Název v anglickém jazyce

Immunonutrition in patients with cyctic fibrosis leads to drop of serum amyloid A and increase of oxidative stress

Popis výsledku anglicky

The aim of the present study is to evaluate of the impact of immunonutrition on parameters of oxidative stress and inflammation in patients with cystic fibrosis and malnutrition. In the 30 patients with cystic fibrosis and long-term enteral nutrition support for malnutrition the effect of standard and immunonutrion sipping on oxidative stress and inflammatory activity parameters was compared. Malonyldialdehyde (MDA) as parameter of oxidative stress and serum amyloid A (SAA), interleukin 1 and 6, hsCRP, IgM, IgA, IgG as parameters of inflammatory activity were examined. Immunonutrition decreased SAA to 17.6 mg/L comparing to 25.6 mg/L when standard nutrition was given (p = 0.014). MDA was 0.66 mu M on standard and 0.96 mu M on immunonutrition support (p &lt; 0.01). The significant negative correlation was recorded between MDA and SAA, hs-CRP, interleukin 6, IgA and IgG. In conclusion, the application of immunonutrition in patients with cystic fibrosis and malnutrition is associated with drop of SAA but with the rise of MDA.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30308 - Nutrition, Dietetics

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Clinical Biochemistry and Nutrition

ISSN

0912-0009

e-ISSN

—

Svazek periodika

60

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

JP - Japonsko

Počet stran výsledku

4

Strana od-do

176-179

Kód UT WoS článku

000403033800005

EID výsledku v databázi Scopus

2-s2.0-85019729452