Replication of SNP associations with keratoconus in a Czech cohort

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10360681" target="_blank" >RIV/00216208:11110/17:10360681 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21230/17:00307680 RIV/00216208:11130/17:10360681 RIV/00064203:_____/17:10360681 RIV/00064165:_____/17:10360681

Výsledek na webu

<a href="http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172365" target="_blank" >http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172365</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0172365" target="_blank" >10.1371/journal.pone.0172365</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Replication of SNP associations with keratoconus in a Czech cohort

Popis výsledku v původním jazyce

Introduction Keratoconus is a relatively frequent disease leading to severe visual impairment. Existing therapies are imperfect and clinical management may benefit from improved understanding of mechanisms leading to this disease. We aim to investigate the replication of 11 single nucleotide polymorphisms (SNPs) with keratoconus. Methods SNPs from loci previously found in association with keratoconus were genotyped in 165 keratoconus cases of Caucasian Czech origin (108 males and 57 females) and 193 population and gender-matched controls. They included rs1536482 (COL5A1), rs4839200 (KCND3), rs757 219 and rs214884 (IMMP2L), rs1328083 and rs1328089 (DAOA), rs2721051 (FOXO1), rs489 4535 (FNDC3B), rs4954218 (MAP3K19, RAB3GAP1), rs9938149 (ZNF469) and rs1324183 (MPDZ). A case-control association analysis was assessed using Fisher&apos;s exact tests. Results The strongest association was found for rs1324183 (allelic test OR = 1.58; 95% CI, 1.10 - 2.24, p = 0.01). Statistically significant values were also obtained for rs2721051 (allelic test OR = 1.72; 95% CI, 1.07 - 2.77, p = 0.025) and rs4954218 (allelic test OR = 1.53; 95% CI, 1.01 - 2.34; p = 0.047) which showed an opposite effect direction compared to previously reported one. Conclusion Independent replication of association between two SNPs and keratoconus supports the association of these loci with the risks for the disease development, while the effect of rs4954218 warrants further investigation. Understanding the role of the genetic factors

Název v anglickém jazyce

Replication of SNP associations with keratoconus in a Czech cohort

Popis výsledku anglicky

Introduction Keratoconus is a relatively frequent disease leading to severe visual impairment. Existing therapies are imperfect and clinical management may benefit from improved understanding of mechanisms leading to this disease. We aim to investigate the replication of 11 single nucleotide polymorphisms (SNPs) with keratoconus. Methods SNPs from loci previously found in association with keratoconus were genotyped in 165 keratoconus cases of Caucasian Czech origin (108 males and 57 females) and 193 population and gender-matched controls. They included rs1536482 (COL5A1), rs4839200 (KCND3), rs757 219 and rs214884 (IMMP2L), rs1328083 and rs1328089 (DAOA), rs2721051 (FOXO1), rs489 4535 (FNDC3B), rs4954218 (MAP3K19, RAB3GAP1), rs9938149 (ZNF469) and rs1324183 (MPDZ). A case-control association analysis was assessed using Fisher&apos;s exact tests. Results The strongest association was found for rs1324183 (allelic test OR = 1.58; 95% CI, 1.10 - 2.24, p = 0.01). Statistically significant values were also obtained for rs2721051 (allelic test OR = 1.72; 95% CI, 1.07 - 2.77, p = 0.025) and rs4954218 (allelic test OR = 1.53; 95% CI, 1.01 - 2.34; p = 0.047) which showed an opposite effect direction compared to previously reported one. Conclusion Independent replication of association between two SNPs and keratoconus supports the association of these loci with the risks for the disease development, while the effect of rs4954218 warrants further investigation. Understanding the role of the genetic factors

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10600 - Biological sciences

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PLoS One

ISSN

1932-6203

e-ISSN

—

Svazek periodika

12

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

—

Kód UT WoS článku

000394424500125

EID výsledku v databázi Scopus

2-s2.0-85012960751