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MortalitY in candIAc surgery (MYRIAD): A randomizeD controlled trial of volatile anesthetics. Rationale and design

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10364154" target="_blank" >RIV/00216208:11110/17:10364154 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00064165:_____/17:10364154

  • Výsledek na webu

    <a href="http://dx.doi.org/10.1016/j.cct.2017.05.011" target="_blank" >http://dx.doi.org/10.1016/j.cct.2017.05.011</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.cct.2017.05.011" target="_blank" >10.1016/j.cct.2017.05.011</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    MortalitY in candIAc surgery (MYRIAD): A randomizeD controlled trial of volatile anesthetics. Rationale and design

  • Popis výsledku v původním jazyce

    Objective: There is initial evidence that the use of volatile anesthetics can reduce the postoperative release of cardiac troponin I, the need for inotropic support, and the number of patients requiring prolonged hospitalization following coronary artery bypass graft (CABG) surgery. Nevertheless, small randomized controlled trials have failed to demonstrate a survival advantage. Thus, whether volatile anesthetics improve the postoperative outcome of cardiac surgical patients remains uncertain. An adequately powered randomized controlled trial appears desirable. Design: Single blinded, international, multicenter randomized controlled trial with 1:1 allocation ratio. Setting: Tertiary and University hospitals. Interventions: Patients (n = 10,600) undergoing coronary artery bypass graft will be randomized to receive either volatile anesthetic as part of the anesthetic plan, or total intravenous anesthesia. Measurements and main results: The primary end point of the study will be one-year mortality (any cause). Secondary endpoints will be 30-day mortality; 30-day death or non-fatal myocardial infarction (composite endpoint); cardiac mortality at 30 day and at one year; incidence of hospital re-admission during the one year follow-up period and duration of intensive care unit, and hospital stay. The sample size is based on the hypothesis that volatile anesthetics will reduce 1-year unadjusted mortality from 3% to 2%, using a two-sided alpha error of 0.05, and a power of 0.9. Conclusions: The trial will determine whether the simple intervention of adding a volatile anesthetic, an intervention that can be implemented by all anesthesiologists, can improve one-year survival in patients undergoing coronary artery bypass graft surgery.

  • Název v anglickém jazyce

    MortalitY in candIAc surgery (MYRIAD): A randomizeD controlled trial of volatile anesthetics. Rationale and design

  • Popis výsledku anglicky

    Objective: There is initial evidence that the use of volatile anesthetics can reduce the postoperative release of cardiac troponin I, the need for inotropic support, and the number of patients requiring prolonged hospitalization following coronary artery bypass graft (CABG) surgery. Nevertheless, small randomized controlled trials have failed to demonstrate a survival advantage. Thus, whether volatile anesthetics improve the postoperative outcome of cardiac surgical patients remains uncertain. An adequately powered randomized controlled trial appears desirable. Design: Single blinded, international, multicenter randomized controlled trial with 1:1 allocation ratio. Setting: Tertiary and University hospitals. Interventions: Patients (n = 10,600) undergoing coronary artery bypass graft will be randomized to receive either volatile anesthetic as part of the anesthetic plan, or total intravenous anesthesia. Measurements and main results: The primary end point of the study will be one-year mortality (any cause). Secondary endpoints will be 30-day mortality; 30-day death or non-fatal myocardial infarction (composite endpoint); cardiac mortality at 30 day and at one year; incidence of hospital re-admission during the one year follow-up period and duration of intensive care unit, and hospital stay. The sample size is based on the hypothesis that volatile anesthetics will reduce 1-year unadjusted mortality from 3% to 2%, using a two-sided alpha error of 0.05, and a power of 0.9. Conclusions: The trial will determine whether the simple intervention of adding a volatile anesthetic, an intervention that can be implemented by all anesthesiologists, can improve one-year survival in patients undergoing coronary artery bypass graft surgery.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30223 - Anaesthesiology

Návaznosti výsledku

  • Projekt

  • Návaznosti

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Ostatní

  • Rok uplatnění

    2017

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Contemporary Clinical Trials

  • ISSN

    1551-7144

  • e-ISSN

  • Svazek periodika

    59

  • Číslo periodika v rámci svazku

    August

  • Stát vydavatele periodika

    US - Spojené státy americké

  • Počet stran výsledku

    6

  • Strana od-do

    38-43

  • Kód UT WoS článku

    000405157600005

  • EID výsledku v databázi Scopus

    2-s2.0-85019761836