A simulation of loading doses for vancomycin continuous infusion regimens in intensive care

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10364155" target="_blank" >RIV/00216208:11110/17:10364155 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1080/23744235.2017.1328741" target="_blank" >http://dx.doi.org/10.1080/23744235.2017.1328741</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/23744235.2017.1328741" target="_blank" >10.1080/23744235.2017.1328741</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A simulation of loading doses for vancomycin continuous infusion regimens in intensive care

Popis výsledku v původním jazyce

Background: Delayed achievement of target vancomycin serum concentrations may adversely affect clinical outcomes. The objective of this retrospective study was to compare the prediction accuracy of different body weight descriptors for volume of distribution and to propose an optimal loading dose (LD) for continuous infusion regimens in adults.Methods: Pharmacokinetic variables were computed using one-compartmental analysis. Simulated LDs of vancomycin were evaluated for each patient.Results: Volume of distribution, clearance, and half-life median values (interquartile range) for vancomycin in the study population (n = 30) were 0.45 (0.39-0.61) L.kg(-1), 0.026 (0.015-0.040) L.h(-1).kg(-1), and 10.3 (7.7-21.3) h, respectively. The observed volume of distribution was better predicted by total body weight (TBW) than by the ideal body weight or the adjusted body weight.Conclusions: An LD of 10.7 mg per kg TBW was optimal in our study population. Using this LD, 17.9% of simulated vancomycin serum levels were just below the therapeutic range, only 10.7% concentrations exceeded the target range and no concentration was toxic. The use of a LD would lead to reduced median time to reach target concentrations from 17 to 1h.

Název v anglickém jazyce

A simulation of loading doses for vancomycin continuous infusion regimens in intensive care

Popis výsledku anglicky

Background: Delayed achievement of target vancomycin serum concentrations may adversely affect clinical outcomes. The objective of this retrospective study was to compare the prediction accuracy of different body weight descriptors for volume of distribution and to propose an optimal loading dose (LD) for continuous infusion regimens in adults.Methods: Pharmacokinetic variables were computed using one-compartmental analysis. Simulated LDs of vancomycin were evaluated for each patient.Results: Volume of distribution, clearance, and half-life median values (interquartile range) for vancomycin in the study population (n = 30) were 0.45 (0.39-0.61) L.kg(-1), 0.026 (0.015-0.040) L.h(-1).kg(-1), and 10.3 (7.7-21.3) h, respectively. The observed volume of distribution was better predicted by total body weight (TBW) than by the ideal body weight or the adjusted body weight.Conclusions: An LD of 10.7 mg per kg TBW was optimal in our study population. Using this LD, 17.9% of simulated vancomycin serum levels were just below the therapeutic range, only 10.7% concentrations exceeded the target range and no concentration was toxic. The use of a LD would lead to reduced median time to reach target concentrations from 17 to 1h.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Infectious Diseases

ISSN

2374-4235

e-ISSN

—

Svazek periodika

49

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

674-679

Kód UT WoS článku

000403158500005

EID výsledku v databázi Scopus

2-s2.0-85019210992