Relationship between serum calprotectin (S100A8/9) and clinical, laboratory and ultrasound parameters of disease activity in rheumatoid arthritis: A large cohort study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10364443" target="_blank" >RIV/00216208:11110/17:10364443 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11510/17:10364443 RIV/00023728:_____/17:N0000079

Výsledek na webu

<a href="http://dx.doi.org/10.1371/journal.pone.0183420" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0183420</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0183420" target="_blank" >10.1371/journal.pone.0183420</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Relationship between serum calprotectin (S100A8/9) and clinical, laboratory and ultrasound parameters of disease activity in rheumatoid arthritis: A large cohort study

Popis výsledku v původním jazyce

Background Calprotectin may be a sensitive biomarker of rheumatoid arthritis (RA) disease activity. Objectives In the current study, we investigated whether calprotectin is a better biomarker than CRP for predicting clinical activity and ultrasound parameters in patients with RA. Methods A total of 160 patients with RA underwent clinical (swollen joint count-SJC, tender joint count-TJC, Disease Activity Score-DAS28, Clinical Disease Activity Index-CDAI, and simplified Disease Activity Index-SDAI) and ultrasound (German US7) examination. Clinical and laboratory measures were correlated with ultrasound findings using Spearman&apos;s correlation coefficient. Differences in serum calprotectin levels in patients with variable disease activity according to the DAS28-ESR and CDAI scores were assessed using ANOVA. Multivariate regression analysis was used to determine the predictive values of calprotectin, CRP and SJC for CDAI and PD US synovitis scores. Results Serum calprotectin was significantly associated with DAS28-ESR (r = 0.321, p&lt;0.001), DAS28-CRP (r = 0.346, p&lt;0.001), SDAI (r = 0.305, p&lt;0.001), CDAI (r = 0.279, p&lt;0.001) scores and CRP levels (r = 0.556, p&lt;0.001). Moreover, calprotectin was significantly correlated with GS (r = 0.379, p&lt;0.001) and PD synovitis scores (r = 0.419, p&lt;0.001). The multi-variate regression analysis showed that calprotectin is a better predictor of the CDAI score and PD US synovitis than CRP. Conclusions The results of this study support an additional role of calprotectin in assessing inflammatory activity in patients with RA.

Název v anglickém jazyce

Relationship between serum calprotectin (S100A8/9) and clinical, laboratory and ultrasound parameters of disease activity in rheumatoid arthritis: A large cohort study

Popis výsledku anglicky

Background Calprotectin may be a sensitive biomarker of rheumatoid arthritis (RA) disease activity. Objectives In the current study, we investigated whether calprotectin is a better biomarker than CRP for predicting clinical activity and ultrasound parameters in patients with RA. Methods A total of 160 patients with RA underwent clinical (swollen joint count-SJC, tender joint count-TJC, Disease Activity Score-DAS28, Clinical Disease Activity Index-CDAI, and simplified Disease Activity Index-SDAI) and ultrasound (German US7) examination. Clinical and laboratory measures were correlated with ultrasound findings using Spearman&apos;s correlation coefficient. Differences in serum calprotectin levels in patients with variable disease activity according to the DAS28-ESR and CDAI scores were assessed using ANOVA. Multivariate regression analysis was used to determine the predictive values of calprotectin, CRP and SJC for CDAI and PD US synovitis scores. Results Serum calprotectin was significantly associated with DAS28-ESR (r = 0.321, p&lt;0.001), DAS28-CRP (r = 0.346, p&lt;0.001), SDAI (r = 0.305, p&lt;0.001), CDAI (r = 0.279, p&lt;0.001) scores and CRP levels (r = 0.556, p&lt;0.001). Moreover, calprotectin was significantly correlated with GS (r = 0.379, p&lt;0.001) and PD synovitis scores (r = 0.419, p&lt;0.001). The multi-variate regression analysis showed that calprotectin is a better predictor of the CDAI score and PD US synovitis than CRP. Conclusions The results of this study support an additional role of calprotectin in assessing inflammatory activity in patients with RA.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30226 - Rheumatology

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PLoS One

ISSN

1932-6203

e-ISSN

—

Svazek periodika

12

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

—

Kód UT WoS článku

000408355800058

EID výsledku v databázi Scopus

2-s2.0-85028442983