Effect of Pulsatility on Microcirculation in Patients Treated with Extracorporeal Cardiopulmonary Resuscitation: A Pilot Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10364447" target="_blank" >RIV/00216208:11110/17:10364447 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21730/17:00320088 RIV/00064203:_____/17:10364447 RIV/00064165:_____/17:10364447

Výsledek na webu

<a href="http://dx.doi.org/10.1097/MAT.0000000000000492" target="_blank" >http://dx.doi.org/10.1097/MAT.0000000000000492</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/MAT.0000000000000492" target="_blank" >10.1097/MAT.0000000000000492</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of Pulsatility on Microcirculation in Patients Treated with Extracorporeal Cardiopulmonary Resuscitation: A Pilot Study

Popis výsledku v původním jazyce

The effect of pulsatile blood flow on microcirculation during extracorporeal cardiopulmonary resuscitation (ECPR) is not elucidated; therefore, we designed an observational study comparing sublingual microcirculation in patients with refractory cardiac arrest (CA) with spontaneously pulsatile or low/nonpulsatile blood flow after treatment with ECPR. Microcirculation was assessed with Sidestream Dark Field technology in 12 patients with CA who were treated with ECPR and 12 healthy control subjects. Microcirculatory images were analyzed offline in a blinded fashion, and consensual parameters were determined for the vessels &lt;= 20 mu m. The patients&apos; data, including actual hemodynamic parameters, were documented. Pulsatile blood flow was defined by a pulse pressure (PP) &gt;= 15 mm Hg. Compared with the healthy volunteers, the patients who were treated with ECPR exhibited a significantly lower proportion of perfused capillaries (PPC); other microcirculatory parameters did not differ. The groups of patients with pulsatile (n = 7) versus low/nonpulsatile (n = 5) blood flow did not differ in regards to the collected data and hemodynamic variables (except for the PP and ejection fraction of the left ventricle) as well as microcirculatory parameters. In conclusion, microcirculation appeared to be effectively supported by ECPR in our group of patients with CA with the exception of the PPC. We found only nonsignificant contribution of spontaneous pulsatility to extracorporeal membrane oxygenation-generated microcirculatory blood flow.

Název v anglickém jazyce

Effect of Pulsatility on Microcirculation in Patients Treated with Extracorporeal Cardiopulmonary Resuscitation: A Pilot Study

Popis výsledku anglicky

The effect of pulsatile blood flow on microcirculation during extracorporeal cardiopulmonary resuscitation (ECPR) is not elucidated; therefore, we designed an observational study comparing sublingual microcirculation in patients with refractory cardiac arrest (CA) with spontaneously pulsatile or low/nonpulsatile blood flow after treatment with ECPR. Microcirculation was assessed with Sidestream Dark Field technology in 12 patients with CA who were treated with ECPR and 12 healthy control subjects. Microcirculatory images were analyzed offline in a blinded fashion, and consensual parameters were determined for the vessels &lt;= 20 mu m. The patients&apos; data, including actual hemodynamic parameters, were documented. Pulsatile blood flow was defined by a pulse pressure (PP) &gt;= 15 mm Hg. Compared with the healthy volunteers, the patients who were treated with ECPR exhibited a significantly lower proportion of perfused capillaries (PPC); other microcirculatory parameters did not differ. The groups of patients with pulsatile (n = 7) versus low/nonpulsatile (n = 5) blood flow did not differ in regards to the collected data and hemodynamic variables (except for the PP and ejection fraction of the left ventricle) as well as microcirculatory parameters. In conclusion, microcirculation appeared to be effectively supported by ECPR in our group of patients with CA with the exception of the PPC. We found only nonsignificant contribution of spontaneous pulsatility to extracorporeal membrane oxygenation-generated microcirculatory blood flow.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

<a href="/cs/project/NT13225" target="_blank" >NT13225: Hyperinvazívní přístup k mimonemocniční zástavě srdce s použitím mechanizované masáže, přednemocničního chlazení, mimotělní podpory oběhu a časného invazívního vyšetření ve srovnání se standardní péčí. Randomizovaná srovnávací studie. "Prague OHCA study"</a><br>

Návaznosti

O - Projekt operacniho programu

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ASAIO Journal

ISSN

1058-2916

e-ISSN

—

Svazek periodika

63

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

386-391

Kód UT WoS článku

000408848900007

EID výsledku v databázi Scopus

2-s2.0-85021872899