Accuracy in Diagnosis of Celiac Disease Without Biopsies in Clinical Practice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10364683" target="_blank" >RIV/00216208:11110/17:10364683 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/17:10364683

Výsledek na webu

<a href="http://dx.doi.org/10.1053/j.gastro.2017.06.002" target="_blank" >http://dx.doi.org/10.1053/j.gastro.2017.06.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1053/j.gastro.2017.06.002" target="_blank" >10.1053/j.gastro.2017.06.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Accuracy in Diagnosis of Celiac Disease Without Biopsies in Clinical Practice

Popis výsledku v původním jazyce

Background &amp; Aims: The guidelines of the European Society of Pediatric Gastroenterology, Hepatology, and Nutrition allow for diagnosis of celiac disease without biopsies in children with symptoms and levels of immunoglobulin A against tissue-transglutaminase (TGA-IgA) 10-fold or more the upper limit of normal (ULN), confirmed by detection of endomysium antibodies (EMA) and positivity for HLA-DQ2/DQ8. We performed a large, international prospective study to validate this approach. Conclusions: Children can be accurately diagnosed with celiac disease without biopsy analysis. Diagnosis based on level of TGA-IgA 10-fold or more the ULN, a positive result from the EMA tests in a second blood sample, and the presence of at least 1 symptom could avoid risks and costs of endoscopy for more than half the children with celiac disease worldwide. HLA analysis is not required for accurate diagnosis. Clinical Trial Registration no: DRKS00003555.

Název v anglickém jazyce

Accuracy in Diagnosis of Celiac Disease Without Biopsies in Clinical Practice

Popis výsledku anglicky

Background &amp; Aims: The guidelines of the European Society of Pediatric Gastroenterology, Hepatology, and Nutrition allow for diagnosis of celiac disease without biopsies in children with symptoms and levels of immunoglobulin A against tissue-transglutaminase (TGA-IgA) 10-fold or more the upper limit of normal (ULN), confirmed by detection of endomysium antibodies (EMA) and positivity for HLA-DQ2/DQ8. We performed a large, international prospective study to validate this approach. Conclusions: Children can be accurately diagnosed with celiac disease without biopsy analysis. Diagnosis based on level of TGA-IgA 10-fold or more the ULN, a positive result from the EMA tests in a second blood sample, and the presence of at least 1 symptom could avoid risks and costs of endoscopy for more than half the children with celiac disease worldwide. HLA analysis is not required for accurate diagnosis. Clinical Trial Registration no: DRKS00003555.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30209 - Paediatrics

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Gastroenterology

ISSN

0016-5085

e-ISSN

—

Svazek periodika

153

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

924-935

Kód UT WoS článku

000411835200022

EID výsledku v databázi Scopus

2-s2.0-85031674147