Propafenone for supraventricular arrhythmias in septic shock-Comparison to amiodarone and metoprolol

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10365446" target="_blank" >RIV/00216208:11110/17:10365446 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/17:43913197 RIV/00064165:_____/17:10365446

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jcrc.2017.04.027" target="_blank" >http://dx.doi.org/10.1016/j.jcrc.2017.04.027</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jcrc.2017.04.027" target="_blank" >10.1016/j.jcrc.2017.04.027</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Propafenone for supraventricular arrhythmias in septic shock-Comparison to amiodarone and metoprolol

Popis výsledku v původním jazyce

Purpose: The occurence of supraventricular arrhythmias associate with an unfavourable prognosis in septic shock. Propafenone could be a feasible antiarrhythmic. Materials and methods: Patients collected over a period of 24 months were divided into the three groups based on antiarrhythmic: Group 1(amiodarone), Group 2(propafenone), Group 3(metoprolol). Type of arrhythmia, cardioversion rates, demographic, haemodynamic, laboratory parameters were recorded in the first 24 h. The outcome data were compared between the groups. Results: 234 patients (99.1% ventilated) were included, the prevailing arrhythmia was acute onset atrial fibrillation (AF, 69.7%). Except for the dosage of noradrenaline (0.35(0.14-0.78) in Group1(n = 142) vs 0.25(0.10-0.50), p &lt; 0.01 in Group2(n-78) vs 0.14(0.07-0.25) mu g/kg.min, p &lt; 0.05 in Group3(n-14)) the ejection fraction of left ventricle, rates of renal replacement therapy, arterial lactate and procalcitonin levels were not different between the groups. The cardioversion rate in Group1(74%) was lower than in Group2(89%) and Group3(92%). ICU and 28-day mortalities of Group1 were not significantly higher than in Group2 and Group3. Multivariate analysis demonstrated higher 12-month mortality in Group1 than in Group2 (HR1.58(1.04; 2.38), p = 0.03). Conclusions: Propafenone demonstrated a higher cardioversion rate than amiodarone with a similar impact on the outcome. Patients remaining in acute onset arrhythmia did not demonstrate significantly higher ICU, 28day and 12-month mortalities compared to those successfully cardioverted or to those having chronic AF.

Název v anglickém jazyce

Propafenone for supraventricular arrhythmias in septic shock-Comparison to amiodarone and metoprolol

Popis výsledku anglicky

Purpose: The occurence of supraventricular arrhythmias associate with an unfavourable prognosis in septic shock. Propafenone could be a feasible antiarrhythmic. Materials and methods: Patients collected over a period of 24 months were divided into the three groups based on antiarrhythmic: Group 1(amiodarone), Group 2(propafenone), Group 3(metoprolol). Type of arrhythmia, cardioversion rates, demographic, haemodynamic, laboratory parameters were recorded in the first 24 h. The outcome data were compared between the groups. Results: 234 patients (99.1% ventilated) were included, the prevailing arrhythmia was acute onset atrial fibrillation (AF, 69.7%). Except for the dosage of noradrenaline (0.35(0.14-0.78) in Group1(n = 142) vs 0.25(0.10-0.50), p &lt; 0.01 in Group2(n-78) vs 0.14(0.07-0.25) mu g/kg.min, p &lt; 0.05 in Group3(n-14)) the ejection fraction of left ventricle, rates of renal replacement therapy, arterial lactate and procalcitonin levels were not different between the groups. The cardioversion rate in Group1(74%) was lower than in Group2(89%) and Group3(92%). ICU and 28-day mortalities of Group1 were not significantly higher than in Group2 and Group3. Multivariate analysis demonstrated higher 12-month mortality in Group1 than in Group2 (HR1.58(1.04; 2.38), p = 0.03). Conclusions: Propafenone demonstrated a higher cardioversion rate than amiodarone with a similar impact on the outcome. Patients remaining in acute onset arrhythmia did not demonstrate significantly higher ICU, 28day and 12-month mortalities compared to those successfully cardioverted or to those having chronic AF.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30223 - Anaesthesiology

Projekt

—

Návaznosti

O - Projekt operacniho programu

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Critical Care

ISSN

0883-9441

e-ISSN

—

Svazek periodika

41

Číslo periodika v rámci svazku

October

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

16-23

Kód UT WoS článku

000415210400004

EID výsledku v databázi Scopus

2-s2.0-85020733038