Atherosclerosis and Cardiovascular Risk in Systemic Sclerosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10366814" target="_blank" >RIV/00216208:11110/17:10366814 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023728:_____/17:N0000017

Výsledek na webu

<a href="https://www.intechopen.com/books/systemic-sclerosis/atherosclerosis-and-cardiovascular-risk-in-systemic-sclerosis" target="_blank" >https://www.intechopen.com/books/systemic-sclerosis/atherosclerosis-and-cardiovascular-risk-in-systemic-sclerosis</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5772/67495" target="_blank" >10.5772/67495</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Atherosclerosis and Cardiovascular Risk in Systemic Sclerosis

Popis výsledku v původním jazyce

Atherosclerosis (ATS) has been considered to be a degenerative disease affecting large and medium-sized arteries, resulting in a passive build-up of cholesterol in the artery wall. In the last decade, immune system was proved to play the key role in the pathogenesis of ATS, suggesting ATS to be more progressive and accelerated in chronic inflammatory conditions. Studies in patients with autoimmune diseases, particularly in the most prevalent ones such as rheumatoid arthritis and systemic lupus erythematosus, confirmed the significantly more serious atherosclerotic disease and increased cardiovascular (CV) risk compared to the general population, suggesting these diseases as an independent risk factor for CV diseases. There are only few studies evaluating ATS and CV risk in systemic sclerosis (SSc). Moreover, these studies present contradictory results. Furthermore, it is complicated to differentiate primary vascular affection related to the pathogenesis of SSc from the secondary vascular infliction due to ATS. Nevertheless, most of the studies to date suggest ATS and its clinical manifestations to be more prevalent in SSc. Future studies evaluating larger cohorts of patients are required to determine the relevance of ATS and CV disease and management of these comorbidities in SSc.

Název v anglickém jazyce

Atherosclerosis and Cardiovascular Risk in Systemic Sclerosis

Popis výsledku anglicky

Atherosclerosis (ATS) has been considered to be a degenerative disease affecting large and medium-sized arteries, resulting in a passive build-up of cholesterol in the artery wall. In the last decade, immune system was proved to play the key role in the pathogenesis of ATS, suggesting ATS to be more progressive and accelerated in chronic inflammatory conditions. Studies in patients with autoimmune diseases, particularly in the most prevalent ones such as rheumatoid arthritis and systemic lupus erythematosus, confirmed the significantly more serious atherosclerotic disease and increased cardiovascular (CV) risk compared to the general population, suggesting these diseases as an independent risk factor for CV diseases. There are only few studies evaluating ATS and CV risk in systemic sclerosis (SSc). Moreover, these studies present contradictory results. Furthermore, it is complicated to differentiate primary vascular affection related to the pathogenesis of SSc from the secondary vascular infliction due to ATS. Nevertheless, most of the studies to date suggest ATS and its clinical manifestations to be more prevalent in SSc. Future studies evaluating larger cohorts of patients are required to determine the relevance of ATS and CV disease and management of these comorbidities in SSc.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

30226 - Rheumatology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Systemic sclerosis

ISBN

978-953-51-3547-0

Počet stran výsledku

38

Strana od-do

23-60

Počet stran knihy

205

Název nakladatele

Intech

Místo vydání

Rijeka

Kód UT WoS kapitoly

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