M-4 Muscarinic Receptors and Locomotor Activity Regulation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10369382" target="_blank" >RIV/00216208:11110/17:10369382 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.biomed.cas.cz/physiolres/pdf/66/66_S443.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/66/66_S443.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

M-4 Muscarinic Receptors and Locomotor Activity Regulation

Popis výsledku v původním jazyce

M-4 muscarinic receptors (M-4 MR) represent a subfamily of G-protein coupled receptors serving a substantial role in spontaneous locomotor activity regulation, cognition and modulation of cholinergic system. With increasing body of literature discussing the role of M-4 MR some controversies arose. Thus, we try here to summarize the current evidence regarding the M-4 MR, with the special focus on their role in locomotor activity control. We review the molecular function of M-4 MR in specific brain areas implicated in locomotor regulation, and shortly in other CNS processes that could be connected to locomotor activity. We also focus on brain areas implicated in locomotor activity biorhythm changes like suprachiasmatic nucleus, subparaventricular zone posterior hypothalamic area, striatum and thalamus. Gender-related aspects and differences in locomotor activity in males and females are discussed further.

Název v anglickém jazyce

M-4 Muscarinic Receptors and Locomotor Activity Regulation

Popis výsledku anglicky

M-4 muscarinic receptors (M-4 MR) represent a subfamily of G-protein coupled receptors serving a substantial role in spontaneous locomotor activity regulation, cognition and modulation of cholinergic system. With increasing body of literature discussing the role of M-4 MR some controversies arose. Thus, we try here to summarize the current evidence regarding the M-4 MR, with the special focus on their role in locomotor activity control. We review the molecular function of M-4 MR in specific brain areas implicated in locomotor regulation, and shortly in other CNS processes that could be connected to locomotor activity. We also focus on brain areas implicated in locomotor activity biorhythm changes like suprachiasmatic nucleus, subparaventricular zone posterior hypothalamic area, striatum and thalamus. Gender-related aspects and differences in locomotor activity in males and females are discussed further.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/GA17-03847S" target="_blank" >GA17-03847S: Role M4 muskarinových receptorů v regulaci biorytmů</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

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Svazek periodika

66

Číslo periodika v rámci svazku

Supplement 4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

13

Strana od-do

"S443"-"S455"

Kód UT WoS článku

000422901400002

EID výsledku v databázi Scopus

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