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Long-term donors versus non-donor men: Iron metabolism and the atherosclerotic process

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10375116" target="_blank" >RIV/00216208:11110/18:10375116 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00064173:_____/18:N0000028 RIV/00216208:11120/18:43916472

  • Výsledek na webu

    <a href="https://doi.org/10.1016/j.atherosclerosis.2018.03.009" target="_blank" >https://doi.org/10.1016/j.atherosclerosis.2018.03.009</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.atherosclerosis.2018.03.009" target="_blank" >10.1016/j.atherosclerosis.2018.03.009</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Long-term donors versus non-donor men: Iron metabolism and the atherosclerotic process

  • Popis výsledku v původním jazyce

    Background and aims: The increased iron level and the labile iron pool (LIP) in circulating monocytes are connected to a higher frequency of cardiovascular events. Methods: The study investigates the relationship between LIP in circulating monocytes and markers of iron metabolism and atherosclerosis (inflammation, oxidative stress, endothelial dysfunction and arterial elasticity) in long-term blood donors and non-donor volunteers. Results: We found that donors had significantly higher LIP values than the control group (1.89 +- 0.47 μM vs. 1.50 +- 0.41 μM, p = 0.007). Despite the observed tendency for the donor group to have higher blood pressure, cholesterol, glucose and HOMAR-IR (homeostasis model assessment of insulin resistance), the groups did not differ in inflammatory markers, markers of endothelial dysfunction and markers of impaired arterial elasticity. The donor group had significant changes in iron metabolism (higher serum Fe, ceruloplasmin, and TfR/Ft ratio (transferrin receptor/ferritin ratio) and lower hepcidin, ferritin, and CD163), indicating depletion of body iron stores and activation of iron turnover. Conclusions: LIP seems to be a good marker of iron turnover activity in these individuals despite the lack of a decrease in the hemoglobin concentration. We did not find a significant correlation between LIP levels and atherosclerosis progression in the two groups. However, further studies are needed to assess long-term donorship as a protective factor against atherosclerosis.

  • Název v anglickém jazyce

    Long-term donors versus non-donor men: Iron metabolism and the atherosclerotic process

  • Popis výsledku anglicky

    Background and aims: The increased iron level and the labile iron pool (LIP) in circulating monocytes are connected to a higher frequency of cardiovascular events. Methods: The study investigates the relationship between LIP in circulating monocytes and markers of iron metabolism and atherosclerosis (inflammation, oxidative stress, endothelial dysfunction and arterial elasticity) in long-term blood donors and non-donor volunteers. Results: We found that donors had significantly higher LIP values than the control group (1.89 +- 0.47 μM vs. 1.50 +- 0.41 μM, p = 0.007). Despite the observed tendency for the donor group to have higher blood pressure, cholesterol, glucose and HOMAR-IR (homeostasis model assessment of insulin resistance), the groups did not differ in inflammatory markers, markers of endothelial dysfunction and markers of impaired arterial elasticity. The donor group had significant changes in iron metabolism (higher serum Fe, ceruloplasmin, and TfR/Ft ratio (transferrin receptor/ferritin ratio) and lower hepcidin, ferritin, and CD163), indicating depletion of body iron stores and activation of iron turnover. Conclusions: LIP seems to be a good marker of iron turnover activity in these individuals despite the lack of a decrease in the hemoglobin concentration. We did not find a significant correlation between LIP levels and atherosclerosis progression in the two groups. However, further studies are needed to assess long-term donorship as a protective factor against atherosclerosis.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30201 - Cardiac and Cardiovascular systems

Návaznosti výsledku

  • Projekt

    <a href="/cs/project/NT13671" target="_blank" >NT13671: Reaktivní železo v monocytech a jeho role v procesu aterogeneze</a><br>

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2018

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Atherosclerosis

  • ISSN

    0021-9150

  • e-ISSN

  • Svazek periodika

    272

  • Číslo periodika v rámci svazku

    May

  • Stát vydavatele periodika

    IE - Irsko

  • Počet stran výsledku

    7

  • Strana od-do

    14-20

  • Kód UT WoS článku

    000430383800003

  • EID výsledku v databázi Scopus

    2-s2.0-85043479919