Long-term donors versus non-donor men: Iron metabolism and the atherosclerotic process
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10375116" target="_blank" >RIV/00216208:11110/18:10375116 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00064173:_____/18:N0000028 RIV/00216208:11120/18:43916472
Výsledek na webu
<a href="https://doi.org/10.1016/j.atherosclerosis.2018.03.009" target="_blank" >https://doi.org/10.1016/j.atherosclerosis.2018.03.009</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.atherosclerosis.2018.03.009" target="_blank" >10.1016/j.atherosclerosis.2018.03.009</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Long-term donors versus non-donor men: Iron metabolism and the atherosclerotic process
Popis výsledku v původním jazyce
Background and aims: The increased iron level and the labile iron pool (LIP) in circulating monocytes are connected to a higher frequency of cardiovascular events. Methods: The study investigates the relationship between LIP in circulating monocytes and markers of iron metabolism and atherosclerosis (inflammation, oxidative stress, endothelial dysfunction and arterial elasticity) in long-term blood donors and non-donor volunteers. Results: We found that donors had significantly higher LIP values than the control group (1.89 +- 0.47 μM vs. 1.50 +- 0.41 μM, p = 0.007). Despite the observed tendency for the donor group to have higher blood pressure, cholesterol, glucose and HOMAR-IR (homeostasis model assessment of insulin resistance), the groups did not differ in inflammatory markers, markers of endothelial dysfunction and markers of impaired arterial elasticity. The donor group had significant changes in iron metabolism (higher serum Fe, ceruloplasmin, and TfR/Ft ratio (transferrin receptor/ferritin ratio) and lower hepcidin, ferritin, and CD163), indicating depletion of body iron stores and activation of iron turnover. Conclusions: LIP seems to be a good marker of iron turnover activity in these individuals despite the lack of a decrease in the hemoglobin concentration. We did not find a significant correlation between LIP levels and atherosclerosis progression in the two groups. However, further studies are needed to assess long-term donorship as a protective factor against atherosclerosis.
Název v anglickém jazyce
Long-term donors versus non-donor men: Iron metabolism and the atherosclerotic process
Popis výsledku anglicky
Background and aims: The increased iron level and the labile iron pool (LIP) in circulating monocytes are connected to a higher frequency of cardiovascular events. Methods: The study investigates the relationship between LIP in circulating monocytes and markers of iron metabolism and atherosclerosis (inflammation, oxidative stress, endothelial dysfunction and arterial elasticity) in long-term blood donors and non-donor volunteers. Results: We found that donors had significantly higher LIP values than the control group (1.89 +- 0.47 μM vs. 1.50 +- 0.41 μM, p = 0.007). Despite the observed tendency for the donor group to have higher blood pressure, cholesterol, glucose and HOMAR-IR (homeostasis model assessment of insulin resistance), the groups did not differ in inflammatory markers, markers of endothelial dysfunction and markers of impaired arterial elasticity. The donor group had significant changes in iron metabolism (higher serum Fe, ceruloplasmin, and TfR/Ft ratio (transferrin receptor/ferritin ratio) and lower hepcidin, ferritin, and CD163), indicating depletion of body iron stores and activation of iron turnover. Conclusions: LIP seems to be a good marker of iron turnover activity in these individuals despite the lack of a decrease in the hemoglobin concentration. We did not find a significant correlation between LIP levels and atherosclerosis progression in the two groups. However, further studies are needed to assess long-term donorship as a protective factor against atherosclerosis.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30201 - Cardiac and Cardiovascular systems
Návaznosti výsledku
Projekt
<a href="/cs/project/NT13671" target="_blank" >NT13671: Reaktivní železo v monocytech a jeho role v procesu aterogeneze</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Atherosclerosis
ISSN
0021-9150
e-ISSN
—
Svazek periodika
272
Číslo periodika v rámci svazku
May
Stát vydavatele periodika
IE - Irsko
Počet stran výsledku
7
Strana od-do
14-20
Kód UT WoS článku
000430383800003
EID výsledku v databázi Scopus
2-s2.0-85043479919