[F-18] Fluorodeoxyglucose PET/CT and prediction of histopathological response to neoadjuvant chemotherapy for adenocarcinoma of the oesophagus and oesophagogastric junction

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10375307" target="_blank" >RIV/00216208:11110/18:10375307 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/18:10375307 RIV/00064203:_____/18:10375307 RIV/00023884:_____/18:00007924 RIV/00064165:_____/18:10375307

Výsledek na webu

<a href="https://doi.org/10.1002/bjs.10712" target="_blank" >https://doi.org/10.1002/bjs.10712</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/bjs.10712" target="_blank" >10.1002/bjs.10712</a>

Jazyk výsledku

angličtina

Název v původním jazyce

[F-18] Fluorodeoxyglucose PET/CT and prediction of histopathological response to neoadjuvant chemotherapy for adenocarcinoma of the oesophagus and oesophagogastric junction

Popis výsledku v původním jazyce

BackgroundThe aim of this prospective study was to assess whether [F-18]fluorodeoxyglucose PET can be used to predict histopathological response early in the course of neoadjuvant chemotherapy in patients with adenocarcinoma of the oesophagus and oesophagogastric junction. MethodsFollowing the PET response criteria in solid tumours (PERCIST 1.0) as a standardized method for semiquantitative assessment of metabolic response, FDG-PET/CT was performed before (PET1) and after (PET2) initiation of the first cycle of chemotherapy. The relative changes in the peak standardized uptake value (SUL) and total lesion glycolysis (TLG) between PET1 and PET2 were correlated with histopathological response, defined as less than 50 per cent viable tumour cells in the resection specimen. A receiver operating characteristic (ROC) curve analysis was used to identify the optimal cut-off value with the highest accuracy of histopathological response prediction. ResultsPET2 was performed a median of 16 (range 12-22) days after the start of chemotherapy. Some 27 of 90 patients who underwent surgery had a histopathological response. There was no association between the median SUL or median TLG and the histopathological response. A post hoc analysis in 47 patients with PET2 performed 16days or less after the start of chemotherapy showed that TLG, but not SUL, was associated with the histopathological response (P=0009). The optimal cut-off value of TLG was 66 per cent or more. ConclusionFDG-PET/CT after the first cycle of chemotherapy does not predict histopathological response in patients with adenocarcinoma of the oesophagus and oesophagogastric junction. Of no use

Název v anglickém jazyce

[F-18] Fluorodeoxyglucose PET/CT and prediction of histopathological response to neoadjuvant chemotherapy for adenocarcinoma of the oesophagus and oesophagogastric junction

Popis výsledku anglicky

BackgroundThe aim of this prospective study was to assess whether [F-18]fluorodeoxyglucose PET can be used to predict histopathological response early in the course of neoadjuvant chemotherapy in patients with adenocarcinoma of the oesophagus and oesophagogastric junction. MethodsFollowing the PET response criteria in solid tumours (PERCIST 1.0) as a standardized method for semiquantitative assessment of metabolic response, FDG-PET/CT was performed before (PET1) and after (PET2) initiation of the first cycle of chemotherapy. The relative changes in the peak standardized uptake value (SUL) and total lesion glycolysis (TLG) between PET1 and PET2 were correlated with histopathological response, defined as less than 50 per cent viable tumour cells in the resection specimen. A receiver operating characteristic (ROC) curve analysis was used to identify the optimal cut-off value with the highest accuracy of histopathological response prediction. ResultsPET2 was performed a median of 16 (range 12-22) days after the start of chemotherapy. Some 27 of 90 patients who underwent surgery had a histopathological response. There was no association between the median SUL or median TLG and the histopathological response. A post hoc analysis in 47 patients with PET2 performed 16days or less after the start of chemotherapy showed that TLG, but not SUL, was associated with the histopathological response (P=0009). The optimal cut-off value of TLG was 66 per cent or more. ConclusionFDG-PET/CT after the first cycle of chemotherapy does not predict histopathological response in patients with adenocarcinoma of the oesophagus and oesophagogastric junction. Of no use

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30212 - Surgery

Projekt

<a href="/cs/project/NT12331" target="_blank" >NT12331: Časné hodnocení efektivity neoadjuvantní chemoterapie u karcinomu jícnu a ezofago-gastrické junkce pomocí FDG-PET/CT vyšetření.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

British Journal of Surgery

ISSN

0007-1323

e-ISSN

—

Svazek periodika

105

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

419-428

Kód UT WoS článku

000426495200014

EID výsledku v databázi Scopus

2-s2.0-85041647706