Dietary patterns, cost and compliance with low-protein diet of phenylketonuria and other inherited metabolic diseases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376311" target="_blank" >RIV/00216208:11110/18:10376311 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61384399:31120/18:00050753 RIV/00064165:_____/18:10376311

Výsledek na webu

<a href="https://doi.org/10.1038/ejcn.2017.102" target="_blank" >https://doi.org/10.1038/ejcn.2017.102</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/ejcn.2017.102" target="_blank" >10.1038/ejcn.2017.102</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dietary patterns, cost and compliance with low-protein diet of phenylketonuria and other inherited metabolic diseases

Popis výsledku v původním jazyce

Background/Objectives: Phenylketonuria (PKU) and several other inherited metabolic diseases (IMD) require a lifelong low-protein diet (LPD), otherwise they lead to many health complications. LPDs, however, carry a significant economic burden for patients and their families. The objective of this study was to explore the costs of low-protein foods (LPFs) necessary for LPD as well as dietary patterns and compliance towards an LPD. Subjects/Methods: A detailed questionnaire was created in cooperation with National Association of PKU and other IMD (NSPKU), and consequently sent to all NSPKU members treated with an LPD (n = 303). A total of 184 respondents from the Czech Republic were included in the study (174 had PKU, 10 had other IMD). Results: The average daily consumption of LPF was equal to 411.7 g (PKU) and 345.6 g (other IMD), which corresponds to energy value of 5558 kJ and 4438 kJ, respectively, per patient per day. Patients mostly consumed low-protein flour (approximate to 30% of energy intake), pasta (approximate to 18%), basic pastry (approximate to 15%) and sweets (approximate to 10%). The average monthly costs of LPDs were equal to EUR130 (PKU) and EUR129 (other IMD) per patient per month. The compliance with LPD was decreasing with increasing age (P &lt; 0.0001). Conclusions: This is the largest study examining costs and dietary patterns of LPDs in patients with PKU and the first study of this kind in other IMD patients requiring an LPD. The study clearly showed that an LPD carries a very high economic burden for families, which may lead to less LPD compliance and potential severe health consequences.

Název v anglickém jazyce

Dietary patterns, cost and compliance with low-protein diet of phenylketonuria and other inherited metabolic diseases

Popis výsledku anglicky

Background/Objectives: Phenylketonuria (PKU) and several other inherited metabolic diseases (IMD) require a lifelong low-protein diet (LPD), otherwise they lead to many health complications. LPDs, however, carry a significant economic burden for patients and their families. The objective of this study was to explore the costs of low-protein foods (LPFs) necessary for LPD as well as dietary patterns and compliance towards an LPD. Subjects/Methods: A detailed questionnaire was created in cooperation with National Association of PKU and other IMD (NSPKU), and consequently sent to all NSPKU members treated with an LPD (n = 303). A total of 184 respondents from the Czech Republic were included in the study (174 had PKU, 10 had other IMD). Results: The average daily consumption of LPF was equal to 411.7 g (PKU) and 345.6 g (other IMD), which corresponds to energy value of 5558 kJ and 4438 kJ, respectively, per patient per day. Patients mostly consumed low-protein flour (approximate to 30% of energy intake), pasta (approximate to 18%), basic pastry (approximate to 15%) and sweets (approximate to 10%). The average monthly costs of LPDs were equal to EUR130 (PKU) and EUR129 (other IMD) per patient per month. The compliance with LPD was decreasing with increasing age (P &lt; 0.0001). Conclusions: This is the largest study examining costs and dietary patterns of LPDs in patients with PKU and the first study of this kind in other IMD patients requiring an LPD. The study clearly showed that an LPD carries a very high economic burden for families, which may lead to less LPD compliance and potential severe health consequences.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30308 - Nutrition, Dietetics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Clinical Nutrition

ISSN

0954-3007

e-ISSN

—

Svazek periodika

72

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

87-92

Kód UT WoS článku

000419795000011

EID výsledku v databázi Scopus

2-s2.0-85040321157