Late relapse in stage I of nonseminomatous germ cell testicular cancer on surveillance

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376437" target="_blank" >RIV/00216208:11110/18:10376437 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.4149/BLL_2018_001" target="_blank" >https://doi.org/10.4149/BLL_2018_001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/BLL_2018_001" target="_blank" >10.4149/BLL_2018_001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Late relapse in stage I of nonseminomatous germ cell testicular cancer on surveillance

Popis výsledku v původním jazyce

OBJECTIVE: Primary aim was to assess relapse-free survival (RFS) in patients with clinical stage I (CS I) of non-seminomatous germ cell testicular tumors (NSGCTT) undergoing surveillance after orchiectomy. The secondary aim was to examine differences in risk factors in patients with early relapse (ER &lt; 2 years), late relapse (LR &gt; 2 years) and very late relapse (VLR &gt; 5 years). METHODS: Cross-sectional study analyzed 25-year single-center experiences with 198 CS I NSGCTT patients according the time to relapse. RESULTS: RFS was 160/198 (80.8 %). Relapse occurred in 38 (19.2 %) patients after a median follow-up of 7.57 months, 33 (86.8 %) patients had ER after a median follow-up of 7.03 months and 5 patients had LR (13.2 %) after a median follow-up of 26.28 months. One patient (2.63 %) had VLR after follow-up &gt; 5 years (7.17 years). Three relapsed patients died with metastatic disease after a mean follow-up of 5.1 years from the date of diagnosis. Another three patients died without cancer after a mean follow-up of two years. OS was 192/198 (97 %). CONCLUSION: Diagnosis and treatment of late relapsing NSGCTT patients should be performed in experienced centers only. Occurrence of LR is the reason for long-term monitoring of NSGCTT survivors.

Název v anglickém jazyce

Late relapse in stage I of nonseminomatous germ cell testicular cancer on surveillance

Popis výsledku anglicky

OBJECTIVE: Primary aim was to assess relapse-free survival (RFS) in patients with clinical stage I (CS I) of non-seminomatous germ cell testicular tumors (NSGCTT) undergoing surveillance after orchiectomy. The secondary aim was to examine differences in risk factors in patients with early relapse (ER &lt; 2 years), late relapse (LR &gt; 2 years) and very late relapse (VLR &gt; 5 years). METHODS: Cross-sectional study analyzed 25-year single-center experiences with 198 CS I NSGCTT patients according the time to relapse. RESULTS: RFS was 160/198 (80.8 %). Relapse occurred in 38 (19.2 %) patients after a median follow-up of 7.57 months, 33 (86.8 %) patients had ER after a median follow-up of 7.03 months and 5 patients had LR (13.2 %) after a median follow-up of 26.28 months. One patient (2.63 %) had VLR after follow-up &gt; 5 years (7.17 years). Three relapsed patients died with metastatic disease after a mean follow-up of 5.1 years from the date of diagnosis. Another three patients died without cancer after a mean follow-up of two years. OS was 192/198 (97 %). CONCLUSION: Diagnosis and treatment of late relapsing NSGCTT patients should be performed in experienced centers only. Occurrence of LR is the reason for long-term monitoring of NSGCTT survivors.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bratislavské lekárske listy

ISSN

0006-9248

e-ISSN

—

Svazek periodika

119

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

3

Strana od-do

3-5

Kód UT WoS článku

000425181900001

EID výsledku v databázi Scopus

2-s2.0-85042108919