The role of obesity and adipose tissue dysfunction in gestational diabetes mellitus

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376819" target="_blank" >RIV/00216208:11110/18:10376819 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/18:43916892 RIV/00023761:_____/18:N0000024 RIV/00064173:_____/18:N0000033 RIV/00023001:_____/18:00077069 RIV/00064165:_____/18:10376819

Výsledek na webu

<a href="https://doi.org/10.1530/JOE-18-0032" target="_blank" >https://doi.org/10.1530/JOE-18-0032</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1530/JOE-18-0032" target="_blank" >10.1530/JOE-18-0032</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The role of obesity and adipose tissue dysfunction in gestational diabetes mellitus

Popis výsledku v původním jazyce

Gestational diabetes mellitus is defined as diabetes diagnosed in the second or third trimester of pregnancy in patients with no history of diabetes prior to gestation. It is the most common complication of pregnancy. The underlying pathophysiology shares some common features with type 2 diabetes mellitus (T2DM) combining relatively insufficient insulin secretion with increased peripheral insulin resistance. While a certain degree of insulin resistance is the physiological characteristics of the second half of pregnancy, it is significantly more pronounced in patients with gestational diabetes. Adipose tissue dysfunction and subclinical inflammation in obesity are well-described causes of increased insulin resistance in non-pregnant subjects and are often observed in individuals with T2DM. Emerging evidence of altered adipokine expression and local inflammation in adipose tissue in patients with gestational diabetes suggests an important involvement of adipose tissue in its etiopathogenesis. This review aims to summarize current knowledge of adipose tissue dysfunction and its role in the development of gestational diabetes. We specifically focus on the significance of alterations of adipokines and immunocompetent cells number and phenotype in fat. Detailed understanding of the role of adipose tissue in gestational diabetes may provide new insights into its pathophysiology and open new possibilities of its prevention and treatment.

Název v anglickém jazyce

The role of obesity and adipose tissue dysfunction in gestational diabetes mellitus

Popis výsledku anglicky

Gestational diabetes mellitus is defined as diabetes diagnosed in the second or third trimester of pregnancy in patients with no history of diabetes prior to gestation. It is the most common complication of pregnancy. The underlying pathophysiology shares some common features with type 2 diabetes mellitus (T2DM) combining relatively insufficient insulin secretion with increased peripheral insulin resistance. While a certain degree of insulin resistance is the physiological characteristics of the second half of pregnancy, it is significantly more pronounced in patients with gestational diabetes. Adipose tissue dysfunction and subclinical inflammation in obesity are well-described causes of increased insulin resistance in non-pregnant subjects and are often observed in individuals with T2DM. Emerging evidence of altered adipokine expression and local inflammation in adipose tissue in patients with gestational diabetes suggests an important involvement of adipose tissue in its etiopathogenesis. This review aims to summarize current knowledge of adipose tissue dysfunction and its role in the development of gestational diabetes. We specifically focus on the significance of alterations of adipokines and immunocompetent cells number and phenotype in fat. Detailed understanding of the role of adipose tissue in gestational diabetes may provide new insights into its pathophysiology and open new possibilities of its prevention and treatment.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

<a href="/cs/project/NV15-27630A" target="_blank" >NV15-27630A: Úloha endokrinní funkce tukové tkáně v etiopatogenezi gestačního diabetu.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Endocrinology

ISSN

0022-0795

e-ISSN

—

Svazek periodika

238

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

15

Strana od-do

"R63"-"R77"

Kód UT WoS článku

000438707700001

EID výsledku v databázi Scopus

2-s2.0-85049487936