Low Cerebral Oxygenation Is Associated with Cognitive Impairment in Chronic Hemodialysis Patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376908" target="_blank" >RIV/00216208:11110/18:10376908 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/18:10376908

Výsledek na webu

<a href="https://doi.org/10.1159/000487092" target="_blank" >https://doi.org/10.1159/000487092</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000487092" target="_blank" >10.1159/000487092</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Low Cerebral Oxygenation Is Associated with Cognitive Impairment in Chronic Hemodialysis Patients

Popis výsledku v původním jazyce

Background/Aims: High rates of cognitive impairment (CI) are an alarming problem in patients undergoing chronic hemodialysis (HD). Its pathophysiology remains unclear and there are indications that brain ischemia might be one of the key causes. Cerebral tissue oxygenation, as measured by near-infrared spectroscopy, is known to be decreased in HD patients. However, it is unknown whether CI is associated or not associated with lower cerebral oxygenation in these patients. The primary aim of our study was to probe this possible association. Our secondary aim was to assess other factors possibly related to cerebral ischemia and CI. Methods: Thirty-nine patients treated by chronic HD were included in this cross-sectional study. All measurements were performed before the initiation of an HD session. The Montreal Cognitive Assessment (MoCA) was administered according to published recommendations. Regional saturation of oxygen (rSO2) of the left frontal lobe was measured using the INVOS 5100C device. Basic medical history and laboratory data were recorded, and handgrip strength was analyzed. We used the unpaired t test to compare the rSO2 and other variables between cognitively normal patients (MoCA score &gt;= 26) and those who displayed CI (MoCA score &lt; 26). Multiple linear regression analysis was used to adjust for principal confounders. Results: Cognitively impaired patients had lower brain rSO2 values compared to cognitively normal patients (48 +/- 9 vs. 57 +/- 10%, p = 0.01). Among other variables, higher red cell distribution width (15.8 +/- 1.9 vs. 13.8 +/- 1.6%, p = 0.01) and lower hand grip strength (49.2 +/- 23.3 vs. 99.3 +/- 31.4 lbs, p &lt; 0.001) also displayed a significant association with CI. The relation between rSO2 and MoCA score was significant after adjustment for age and gender (p = 0.007). Conclusion: Decreased brain oxygenation is associated with weaker cognitive performance in patients undergoing chronic HD. Further understanding the causes of cerebral ischemia in HD patients could lead to the prevention of cognitive decline in this population.

Název v anglickém jazyce

Low Cerebral Oxygenation Is Associated with Cognitive Impairment in Chronic Hemodialysis Patients

Popis výsledku anglicky

Background/Aims: High rates of cognitive impairment (CI) are an alarming problem in patients undergoing chronic hemodialysis (HD). Its pathophysiology remains unclear and there are indications that brain ischemia might be one of the key causes. Cerebral tissue oxygenation, as measured by near-infrared spectroscopy, is known to be decreased in HD patients. However, it is unknown whether CI is associated or not associated with lower cerebral oxygenation in these patients. The primary aim of our study was to probe this possible association. Our secondary aim was to assess other factors possibly related to cerebral ischemia and CI. Methods: Thirty-nine patients treated by chronic HD were included in this cross-sectional study. All measurements were performed before the initiation of an HD session. The Montreal Cognitive Assessment (MoCA) was administered according to published recommendations. Regional saturation of oxygen (rSO2) of the left frontal lobe was measured using the INVOS 5100C device. Basic medical history and laboratory data were recorded, and handgrip strength was analyzed. We used the unpaired t test to compare the rSO2 and other variables between cognitively normal patients (MoCA score &gt;= 26) and those who displayed CI (MoCA score &lt; 26). Multiple linear regression analysis was used to adjust for principal confounders. Results: Cognitively impaired patients had lower brain rSO2 values compared to cognitively normal patients (48 +/- 9 vs. 57 +/- 10%, p = 0.01). Among other variables, higher red cell distribution width (15.8 +/- 1.9 vs. 13.8 +/- 1.6%, p = 0.01) and lower hand grip strength (49.2 +/- 23.3 vs. 99.3 +/- 31.4 lbs, p &lt; 0.001) also displayed a significant association with CI. The relation between rSO2 and MoCA score was significant after adjustment for age and gender (p = 0.007). Conclusion: Decreased brain oxygenation is associated with weaker cognitive performance in patients undergoing chronic HD. Further understanding the causes of cerebral ischemia in HD patients could lead to the prevention of cognitive decline in this population.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30217 - Urology and nephrology

Projekt

<a href="/cs/project/NV17-31796A" target="_blank" >NV17-31796A: Tkáňová hypoxie u pacientů s chronickým onemocněním ledvin – metabolické a hemodynamické souvislosti</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nephron

ISSN

1660-8151

e-ISSN

—

Svazek periodika

139

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

113-119

Kód UT WoS článku

000433957700001

EID výsledku v databázi Scopus

2-s2.0-85042118011