Lower serum clusterin levels in patients with erosive hand osteoarthritis are associated with more pain

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10377542" target="_blank" >RIV/00216208:11110/18:10377542 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023728:_____/18:N0000048

Výsledek na webu

<a href="https://doi.org/10.1186/s12891-018-2179-3" target="_blank" >https://doi.org/10.1186/s12891-018-2179-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12891-018-2179-3" target="_blank" >10.1186/s12891-018-2179-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Lower serum clusterin levels in patients with erosive hand osteoarthritis are associated with more pain

Popis výsledku v původním jazyce

Background: The aims of this study were to analyse the serum concentrations of clusterin (CLU) in patients with hand osteoarthritis (OA) and in healthy controls, to compare CLU levels between patients with erosive and non-erosive disease, and to examine the association of CLU levels with clinical and laboratory parameters. Methods: A total of 135 patients with hand OA (81 with erosive and 54 with non-erosive disease) and 53 healthy individuals were included in this study. All patients underwent clinical and hand joint ultrasound examination. The Australian/Canadian (AUSCAN) hand osteoarthritis index, algofunctional index and a visual analogue scale (VAS) for the measurement of pain were assessed. Serum levels of CLU were measured by an enzyme-linked immunosorbent assay (ELISA). Results: Serum levels of CLU were significantly lower in patients with hand OA than in control subjects (p &lt; 0.0001). In addition, patients with erosive hand OA had significantly lower CLU levels than those with non-erosive disease (p = 0.044). Negative correlations between CLU levels and pain as assessed by the AUSCAN score and the VAS were found in patients with erosive hand OA (r = -0.275; p = 0.013 and r= -0.220; p = 0.049, respectively). Conclusion: The present study demonstrates that lower concentrations of CLU are found in hand OA patients than in healthy individuals, especially in those with erosive disease, and that CLU concentrations have a negative association with hand pain.

Název v anglickém jazyce

Lower serum clusterin levels in patients with erosive hand osteoarthritis are associated with more pain

Popis výsledku anglicky

Background: The aims of this study were to analyse the serum concentrations of clusterin (CLU) in patients with hand osteoarthritis (OA) and in healthy controls, to compare CLU levels between patients with erosive and non-erosive disease, and to examine the association of CLU levels with clinical and laboratory parameters. Methods: A total of 135 patients with hand OA (81 with erosive and 54 with non-erosive disease) and 53 healthy individuals were included in this study. All patients underwent clinical and hand joint ultrasound examination. The Australian/Canadian (AUSCAN) hand osteoarthritis index, algofunctional index and a visual analogue scale (VAS) for the measurement of pain were assessed. Serum levels of CLU were measured by an enzyme-linked immunosorbent assay (ELISA). Results: Serum levels of CLU were significantly lower in patients with hand OA than in control subjects (p &lt; 0.0001). In addition, patients with erosive hand OA had significantly lower CLU levels than those with non-erosive disease (p = 0.044). Negative correlations between CLU levels and pain as assessed by the AUSCAN score and the VAS were found in patients with erosive hand OA (r = -0.275; p = 0.013 and r= -0.220; p = 0.049, respectively). Conclusion: The present study demonstrates that lower concentrations of CLU are found in hand OA patients than in healthy individuals, especially in those with erosive disease, and that CLU concentrations have a negative association with hand pain.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30226 - Rheumatology

Projekt

<a href="/cs/project/NV18-01-00542" target="_blank" >NV18-01-00542: Prognostické faktory progrese erozivní osteoartrózy rukou</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BMC Musculoskeletal Disorders

ISSN

1471-2474

e-ISSN

—

Svazek periodika

19

Číslo periodika v rámci svazku

July

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

—

Kód UT WoS článku

000440225600007

EID výsledku v databázi Scopus

2-s2.0-85050723088