19F Magnetic Resonance Imaging of Injectable Polymeric Implants with Multiresponsive Behavior

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10378670" target="_blank" >RIV/00216208:11110/18:10378670 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389013:_____/18:00492562

Výsledek na webu

<a href="https://doi.org/10.1021/acs.chemmater.8b02115" target="_blank" >https://doi.org/10.1021/acs.chemmater.8b02115</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.chemmater.8b02115" target="_blank" >10.1021/acs.chemmater.8b02115</a>

Jazyk výsledku

angličtina

Název v původním jazyce

19F Magnetic Resonance Imaging of Injectable Polymeric Implants with Multiresponsive Behavior

Popis výsledku v původním jazyce

Recently, magnetic resonance imaging (MRI) probes based on fluorinated compounds have emerged as highly promising contrast agents. Direct imaging of injectable thermoresponsive polymer implants by 19F MRI represents an attractive, as yet unreported tool for the straightforward and non-invasive monitoring of implant localization, size, morphology, and biodegradation. Herein, we describe for the first time the in vivo 19f MRI visualization of such implants. These were subcutaneously and intramuscularly administered as an aqueous solution to form a traceable solid implant upon the change of temperature and pH. After formation, the polymer implant was effectively visualized by 19F MRI. The kinetics of the implant degradation is suitable for application as injectable drug depots or in the local radiotherapy of solid tumors.

Název v anglickém jazyce

19F Magnetic Resonance Imaging of Injectable Polymeric Implants with Multiresponsive Behavior

Popis výsledku anglicky

Recently, magnetic resonance imaging (MRI) probes based on fluorinated compounds have emerged as highly promising contrast agents. Direct imaging of injectable thermoresponsive polymer implants by 19F MRI represents an attractive, as yet unreported tool for the straightforward and non-invasive monitoring of implant localization, size, morphology, and biodegradation. Herein, we describe for the first time the in vivo 19f MRI visualization of such implants. These were subcutaneously and intramuscularly administered as an aqueous solution to form a traceable solid implant upon the change of temperature and pH. After formation, the polymer implant was effectively visualized by 19F MRI. The kinetics of the implant degradation is suitable for application as injectable drug depots or in the local radiotherapy of solid tumors.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

<a href="/cs/project/GA16-03156S" target="_blank" >GA16-03156S: Samouspořádané polymerní nanostruktury jako bimodální kontrastní látky pro zobrazení magnetickou rezonancí a ultrazvukem</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemistry of Materials

ISSN

0897-4756

e-ISSN

—

Svazek periodika

30

Číslo periodika v rámci svazku

15

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

4892-4896

Kód UT WoS článku

000442186500005

EID výsledku v databázi Scopus

2-s2.0-85050621317