Altered Immunity in Endometriosis: What Came First?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10378713" target="_blank" >RIV/00216208:11110/18:10378713 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11140/18:10378713 RIV/00669806:_____/18:10378713

Výsledek na webu

<a href="https://doi.org/10.1080/08820139.2018.1467926" target="_blank" >https://doi.org/10.1080/08820139.2018.1467926</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/08820139.2018.1467926" target="_blank" >10.1080/08820139.2018.1467926</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Altered Immunity in Endometriosis: What Came First?

Popis výsledku v původním jazyce

Background: This study was conducted to summarize current knowledge of the changes within the immune system, from action of macrophages, lymphocytes and NK cells to biological effects of their products. Endometriosis is a complex gynecological disorder defined as a presence of endometrial tissue outside the uterus affecting over 5 million reproductive-aged women in the U.S. alone.Result: In recent years, the potential role of the immune system in the development of endometriosis has increasingly gained attention. Data summarized in our study showed that the most relevant immunocytes are macrophages residing inside the peritoneal cavity and the ratios of Th1 to Th2 cells. Another crucial immunological parameter is the balance in production of cytokines and chemoatractants.Conclusions: This review confirms that despite decades of intensive research, the involvement of the immune system remains elusive, as we can recognize the changes, but still do not understand if these changes represent the results of endometriosis or if they are contributing factors. Based on these findings, we also discuss new treatment possibilities.

Název v anglickém jazyce

Altered Immunity in Endometriosis: What Came First?

Popis výsledku anglicky

Background: This study was conducted to summarize current knowledge of the changes within the immune system, from action of macrophages, lymphocytes and NK cells to biological effects of their products. Endometriosis is a complex gynecological disorder defined as a presence of endometrial tissue outside the uterus affecting over 5 million reproductive-aged women in the U.S. alone.Result: In recent years, the potential role of the immune system in the development of endometriosis has increasingly gained attention. Data summarized in our study showed that the most relevant immunocytes are macrophages residing inside the peritoneal cavity and the ratios of Th1 to Th2 cells. Another crucial immunological parameter is the balance in production of cytokines and chemoatractants.Conclusions: This review confirms that despite decades of intensive research, the involvement of the immune system remains elusive, as we can recognize the changes, but still do not understand if these changes represent the results of endometriosis or if they are contributing factors. Based on these findings, we also discuss new treatment possibilities.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Immunological Investigations

ISSN

0882-0139

e-ISSN

—

Svazek periodika

47

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

569-582

Kód UT WoS článku

000438120000004

EID výsledku v databázi Scopus

2-s2.0-85049674238