Modern and traditional approaches combined into an effective gray-box mathematical model of full-blood acid-base

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10380846" target="_blank" >RIV/00216208:11110/18:10380846 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21230/18:00327588

Výsledek na webu

<a href="https://doi.org/10.1186/s12976-018-0086-9" target="_blank" >https://doi.org/10.1186/s12976-018-0086-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12976-018-0086-9" target="_blank" >10.1186/s12976-018-0086-9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Modern and traditional approaches combined into an effective gray-box mathematical model of full-blood acid-base

Popis výsledku v původním jazyce

Background: The acidity of human body fluids, expressed by the pH, is physiologically regulated in a narrow range, which is required for the proper function of cellular metabolism. Acid-base disorders are common especially in intensive care, and the acid-base status is one of the vital clinical signs for the patient management. Because acid-base balance is connected to many bodily processes and regulations, complex mathematical models are needed to get insight into the mixed disorders and to act accordingly. The goal of this study is to develop a full-blood acid-base model, designed to be further integrated into more complex human physiology models. Results: We have developed computationally simple and robust full-blood model, yet thorough enough to cover most of the common pathologies. Thanks to its simplicity and usage of Modelica language, it is suitable to be embedded within more elaborate systems. We achieved the simplification by a combination of behavioral Siggaard-Andersen&apos;s traditional approach for erythrocyte modeling and the mechanistic Stewart&apos;s physicochemical approach for plasma modeling. The resulting model is capable of providing variations in arterial pCO2, base excess, strong ion difference, hematocrit, plasma protein, phosphates and hemodilution/hemoconcentration, but insensitive to DPG and CO concentrations. Conclusions: This study presents a straightforward unification of Siggaard-Andersen&apos;s and Stewart&apos;s acid-base models. The resulting full-blood acid-base model is designed to be a core part of a complex dynamic whole-body acid base and gas transfer model.

Název v anglickém jazyce

Modern and traditional approaches combined into an effective gray-box mathematical model of full-blood acid-base

Popis výsledku anglicky

Background: The acidity of human body fluids, expressed by the pH, is physiologically regulated in a narrow range, which is required for the proper function of cellular metabolism. Acid-base disorders are common especially in intensive care, and the acid-base status is one of the vital clinical signs for the patient management. Because acid-base balance is connected to many bodily processes and regulations, complex mathematical models are needed to get insight into the mixed disorders and to act accordingly. The goal of this study is to develop a full-blood acid-base model, designed to be further integrated into more complex human physiology models. Results: We have developed computationally simple and robust full-blood model, yet thorough enough to cover most of the common pathologies. Thanks to its simplicity and usage of Modelica language, it is suitable to be embedded within more elaborate systems. We achieved the simplification by a combination of behavioral Siggaard-Andersen&apos;s traditional approach for erythrocyte modeling and the mechanistic Stewart&apos;s physicochemical approach for plasma modeling. The resulting model is capable of providing variations in arterial pCO2, base excess, strong ion difference, hematocrit, plasma protein, phosphates and hemodilution/hemoconcentration, but insensitive to DPG and CO concentrations. Conclusions: This study presents a straightforward unification of Siggaard-Andersen&apos;s and Stewart&apos;s acid-base models. The resulting full-blood acid-base model is designed to be a core part of a complex dynamic whole-body acid base and gas transfer model.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30502 - Other medical science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Theoretical Biology and Medical Modelling

ISSN

1742-4682

e-ISSN

—

Svazek periodika

15

Číslo periodika v rámci svazku

14

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

—

Kód UT WoS článku

000444533000001

EID výsledku v databázi Scopus

2-s2.0-85053126310