Cardiac resynchronization therapy guided by cardiac magnetic resonance imaging: A prospective, single-centre randomized study (CMR-CRT)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10382312" target="_blank" >RIV/00216208:11110/18:10382312 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/18:10382312 RIV/00023001:_____/18:00077396

Výsledek na webu

<a href="https://doi.org/10.1016/j.ijcard.2018.06.009" target="_blank" >https://doi.org/10.1016/j.ijcard.2018.06.009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijcard.2018.06.009" target="_blank" >10.1016/j.ijcard.2018.06.009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cardiac resynchronization therapy guided by cardiac magnetic resonance imaging: A prospective, single-centre randomized study (CMR-CRT)

Popis výsledku v původním jazyce

Background: Cardiac resynchronization therapy (CRT) improves symptoms of heart failure (HF), morbidity and mortality in selected population. The aim of the study was to investigate the impact of cardiac magnetic resonance (CMR)-guided left ventricular (LV) lead placement on clinical outcomes and LV reverse remodelling in CRT recipients. Methods: Patients with CRT indication were randomized for CMR-guided (CMR group) or electrophysiologically guided (EP group) LV lead placement between 2011 and 2014. The target site in the CMR group was defined as the most delayed, scar-free, in the EP group as the site with the longest interval between the QRS onset and local electrogram. The primary endpoint was a combination of cardiovascular death or HF hospitalization. Secondary endpoints were New York Heart Association (NYHA) Class improvement &gt;= 1, LV endsystolic diameter reduction N10%, B-type natriuretic peptide reduction by &gt;= 30%. Results: A total of 99 patients (47 in the CMR and 52 in the EP group) were enrolled. During amedian follow-up of 47 months, primary composite endpoint occurred in 5 patients in the CMR group and 14 patients in the EP group (HR=0.46; 95% CI: 0.16-1.32). Patients with left bundle branch block and NYHA Class &gt;2 had better clinical outcome in the CMR group (HR=0.09; 95% CI: 0.01-0.75). Conclusions: The use of CMR did not result in significant reduction of combined endpoint of cardiovascular death or HF hospitalization in the total study population. Significant clinical benefit from CMR-guided procedure was observed in a subgroup of optimum CRT candidates with advanced HF. (c) 2018 Elsevier B.V. All rights reserved.

Název v anglickém jazyce

Cardiac resynchronization therapy guided by cardiac magnetic resonance imaging: A prospective, single-centre randomized study (CMR-CRT)

Popis výsledku anglicky

Background: Cardiac resynchronization therapy (CRT) improves symptoms of heart failure (HF), morbidity and mortality in selected population. The aim of the study was to investigate the impact of cardiac magnetic resonance (CMR)-guided left ventricular (LV) lead placement on clinical outcomes and LV reverse remodelling in CRT recipients. Methods: Patients with CRT indication were randomized for CMR-guided (CMR group) or electrophysiologically guided (EP group) LV lead placement between 2011 and 2014. The target site in the CMR group was defined as the most delayed, scar-free, in the EP group as the site with the longest interval between the QRS onset and local electrogram. The primary endpoint was a combination of cardiovascular death or HF hospitalization. Secondary endpoints were New York Heart Association (NYHA) Class improvement &gt;= 1, LV endsystolic diameter reduction N10%, B-type natriuretic peptide reduction by &gt;= 30%. Results: A total of 99 patients (47 in the CMR and 52 in the EP group) were enrolled. During amedian follow-up of 47 months, primary composite endpoint occurred in 5 patients in the CMR group and 14 patients in the EP group (HR=0.46; 95% CI: 0.16-1.32). Patients with left bundle branch block and NYHA Class &gt;2 had better clinical outcome in the CMR group (HR=0.09; 95% CI: 0.01-0.75). Conclusions: The use of CMR did not result in significant reduction of combined endpoint of cardiovascular death or HF hospitalization in the total study population. Significant clinical benefit from CMR-guided procedure was observed in a subgroup of optimum CRT candidates with advanced HF. (c) 2018 Elsevier B.V. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Cardiology

ISSN

0167-5273

e-ISSN

—

Svazek periodika

270

Číslo periodika v rámci svazku

November

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

325-330

Kód UT WoS článku

000444609000075

EID výsledku v databázi Scopus

2-s2.0-85048322753