Oropharyngeal surfactant can improve initial stabilisation and reduce rescue intubation in infants born below 25weeks of gestation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10385383" target="_blank" >RIV/00216208:11110/18:10385383 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/18:10385383

Výsledek na webu

<a href="https://doi.org/10.1111/apa.14060" target="_blank" >https://doi.org/10.1111/apa.14060</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/apa.14060" target="_blank" >10.1111/apa.14060</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Oropharyngeal surfactant can improve initial stabilisation and reduce rescue intubation in infants born below 25weeks of gestation

Popis výsledku v původním jazyce

Aim: Minimally aggressive and easily performed techniques that facilitate spontaneous respiratory stabilisation are required to reduce rescue intubation in extremely premature infants. This study evaluated the feasibility and safety of administering surfactant into the pharynx of infants born at &lt;25weeks immediately after birth. Methods: This study of 19 infants was conducted from January 2013 to June 2014 in a tertiary perinatal centre in Prague. We administered 1.5mL of Curosurf as a bolus into the pharynx and simultaneously performed a sustained inflation manoeuvre (SIM). The extent of the interventions, death and severe neonatal morbidity in the study group were compared with 20 controls born before the study period and 20 born after it. Results: All infants received oropharyngeal surfactant within the median (interquartile range) time of 40seconds (25-75) after cord camping. The surfactant had to be suctioned in one infant because of upper airway obstruction. Although more subsequent surfactant was administered in the study group, significantly fewer study period infants required intubation than the before and after controls (16% versus 75% and 58%, respectively, p&lt;0.01). Conclusion: Oropharyngeal surfactant with simultaneous SIM was feasible and safe and reduced the need for delivery room intubation in these fragile infants.

Název v anglickém jazyce

Oropharyngeal surfactant can improve initial stabilisation and reduce rescue intubation in infants born below 25weeks of gestation

Popis výsledku anglicky

Aim: Minimally aggressive and easily performed techniques that facilitate spontaneous respiratory stabilisation are required to reduce rescue intubation in extremely premature infants. This study evaluated the feasibility and safety of administering surfactant into the pharynx of infants born at &lt;25weeks immediately after birth. Methods: This study of 19 infants was conducted from January 2013 to June 2014 in a tertiary perinatal centre in Prague. We administered 1.5mL of Curosurf as a bolus into the pharynx and simultaneously performed a sustained inflation manoeuvre (SIM). The extent of the interventions, death and severe neonatal morbidity in the study group were compared with 20 controls born before the study period and 20 born after it. Results: All infants received oropharyngeal surfactant within the median (interquartile range) time of 40seconds (25-75) after cord camping. The surfactant had to be suctioned in one infant because of upper airway obstruction. Although more subsequent surfactant was administered in the study group, significantly fewer study period infants required intubation than the before and after controls (16% versus 75% and 58%, respectively, p&lt;0.01). Conclusion: Oropharyngeal surfactant with simultaneous SIM was feasible and safe and reduced the need for delivery room intubation in these fragile infants.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30214 - Obstetrics and gynaecology

Projekt

—

Návaznosti

O - Projekt operacniho programu

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Paediatrica

ISSN

0803-5253

e-ISSN

—

Svazek periodika

107

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

73-78

Kód UT WoS článku

000417865400014

EID výsledku v databázi Scopus

2-s2.0-85037747847