Acoustic Tracking of Pitch, Modal, and Subharmonic Vibrations of Vocal Folds in Parkinsons Disease and Parkinsonism

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F19%3A10401543" target="_blank" >RIV/00216208:11110/19:10401543 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21230/19:00335345

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=2BjPfygXrd" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=2BjPfygXrd</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1109/ACCESS.2019.2945874" target="_blank" >10.1109/ACCESS.2019.2945874</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Acoustic Tracking of Pitch, Modal, and Subharmonic Vibrations of Vocal Folds in Parkinsons Disease and Parkinsonism

Popis výsledku v původním jazyce

The prominent and early presence of dysphonia is considered a valuable marker for differentiation of idiopathic Parkinsons disease and parkinsonian syndromes. Objective quantification of vibrational regimes represented by modal and subharmonic vibrations may thus be vital for improving accuracy of diagnostic decision. The rationale for analyzing vibrational regimes is that abnormal subharmonic vibrations might be the key factor causing dysphonia in parkinsonian syndromes. This study introduces a new fully automated methodology based on robust pitch tracker for decoupling vibrations controlled by laryngeal muscles from the effect of subharmonics that provides distinguishing features of Parkinsons disease and atypical parkinsonian syndromes. We tested the method on resynthesized signals with known parameters and demonstrated that vibrations controlled by laryngeal muscles as well as subharmonics can be detected reliably with a precision that outperforms available technologies. We analysed 337 sustained vowels of 22 patients with PD, 21 patients with multiple system atrophy, 18 patients with progressive supranuclear palsy and 22 healthy controls. Our results showed that subharmonics are more prominent in atypical parkinsonian syndromes compared to Parkinsons disease. Also, increased modulation by laryngeal muscles appears to be a distinctive symptom of multiple system atrophy. Developed algorithm and proposed resynthesized voice signals provide further critical step to understanding and evaluation of dysphonia in Parkinsonism.

Název v anglickém jazyce

Acoustic Tracking of Pitch, Modal, and Subharmonic Vibrations of Vocal Folds in Parkinsons Disease and Parkinsonism

Popis výsledku anglicky

The prominent and early presence of dysphonia is considered a valuable marker for differentiation of idiopathic Parkinsons disease and parkinsonian syndromes. Objective quantification of vibrational regimes represented by modal and subharmonic vibrations may thus be vital for improving accuracy of diagnostic decision. The rationale for analyzing vibrational regimes is that abnormal subharmonic vibrations might be the key factor causing dysphonia in parkinsonian syndromes. This study introduces a new fully automated methodology based on robust pitch tracker for decoupling vibrations controlled by laryngeal muscles from the effect of subharmonics that provides distinguishing features of Parkinsons disease and atypical parkinsonian syndromes. We tested the method on resynthesized signals with known parameters and demonstrated that vibrations controlled by laryngeal muscles as well as subharmonics can be detected reliably with a precision that outperforms available technologies. We analysed 337 sustained vowels of 22 patients with PD, 21 patients with multiple system atrophy, 18 patients with progressive supranuclear palsy and 22 healthy controls. Our results showed that subharmonics are more prominent in atypical parkinsonian syndromes compared to Parkinsons disease. Also, increased modulation by laryngeal muscles appears to be a distinctive symptom of multiple system atrophy. Developed algorithm and proposed resynthesized voice signals provide further critical step to understanding and evaluation of dysphonia in Parkinsonism.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

IEEE Access

ISSN

2169-3536

e-ISSN

—

Svazek periodika

7

Číslo periodika v rámci svazku

October

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

16

Strana od-do

150339-150354

Kód UT WoS článku

000497160500110

EID výsledku v databázi Scopus

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