Case Study: Methanol mass poisoning outbreak in the Czech Republic: Diagnosis, treatment and outcome

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F19%3A10410716" target="_blank" >RIV/00216208:11110/19:10410716 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/19:10410716

Výsledek na webu

<a href="http://dx.doi.org/10.1039/9781782623687-00263" target="_blank" >http://dx.doi.org/10.1039/9781782623687-00263</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/9781782623687-00263" target="_blank" >10.1039/9781782623687-00263</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Case Study: Methanol mass poisoning outbreak in the Czech Republic: Diagnosis, treatment and outcome

Popis výsledku v původním jazyce

Methanol outbreaks are a global public health issue, with poor outcomes associated with delayed treatment. We report the data from the mass methanol poisoning outbreak in the Czech Republic in 2012-2014. From a total of 137 poisoned subjects, 31 died outside the hospital and 106 were hospitalized. Of these, 83 patients survived. The total and hospital mortality rates were 39% and 22%, respectively. Arterial blood pH under 7.0, negative serum ethanol and coma on admission were the independent parameters predicting death. We found a positive association between out-of-hospital ethanol administration and improved treatment outcome. Both antidotes, fomepizole and ethanol, may be considered for alcohol dehydrogenase blockade in hospital without limitations. Intermittent haemodialysis is superior to continuous modalities in terms of the rate of elimination of both methanol and formate. The prevalence of long-term visual sequelae after methanol poisoning was significantly higher than the prevalence of visual disturbances at the time of discharge from hospital. Altogether, 40% of examined survivors had abnormal morphological and functional findings complying with the criteria of long-term visual damage 3-8 months after discharge. The prevalence of long-term central nervous system sequelae was clearly underestimated at discharge from hospital, as magnetic resonance examination revealed brain lesions in 52% of the survivors.

Název v anglickém jazyce

Case Study: Methanol mass poisoning outbreak in the Czech Republic: Diagnosis, treatment and outcome

Popis výsledku anglicky

Methanol outbreaks are a global public health issue, with poor outcomes associated with delayed treatment. We report the data from the mass methanol poisoning outbreak in the Czech Republic in 2012-2014. From a total of 137 poisoned subjects, 31 died outside the hospital and 106 were hospitalized. Of these, 83 patients survived. The total and hospital mortality rates were 39% and 22%, respectively. Arterial blood pH under 7.0, negative serum ethanol and coma on admission were the independent parameters predicting death. We found a positive association between out-of-hospital ethanol administration and improved treatment outcome. Both antidotes, fomepizole and ethanol, may be considered for alcohol dehydrogenase blockade in hospital without limitations. Intermittent haemodialysis is superior to continuous modalities in terms of the rate of elimination of both methanol and formate. The prevalence of long-term visual sequelae after methanol poisoning was significantly higher than the prevalence of visual disturbances at the time of discharge from hospital. Altogether, 40% of examined survivors had abnormal morphological and functional findings complying with the criteria of long-term visual damage 3-8 months after discharge. The prevalence of long-term central nervous system sequelae was clearly underestimated at discharge from hospital, as magnetic resonance examination revealed brain lesions in 52% of the survivors.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

30108 - Toxicology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Chemical Health Threats: Assessing and Alerting

ISBN

978-1-78262-071-6

Počet stran výsledku

8

Strana od-do

263-270

Počet stran knihy

309

Název nakladatele

The Royal Society of Chemistry

Místo vydání

London

Kód UT WoS kapitoly

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