Mummified cells are a common finding in cutaneous Hodgkin lymphoma and can be used as a diagnostic clue

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10402178" target="_blank" >RIV/00216208:11110/20:10402178 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11140/20:10402178 RIV/00669806:_____/20:10402178 RIV/00064165:_____/20:10402178

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=n.DMKC_iQ0" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=n.DMKC_iQ0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/DAD.0000000000001445" target="_blank" >10.1097/DAD.0000000000001445</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mummified cells are a common finding in cutaneous Hodgkin lymphoma and can be used as a diagnostic clue

Popis výsledku v původním jazyce

Specific cutaneous involvement in Hodgkin lymphoma israre. In cutaneous lesions, the diagnosis is usually based on therecognition of diagnostic Reed-Sternberg cells and its variants. Innodal Hodgkin lymphoma, so-called mummified cells (cells with con-densed cytoplasm and pyknotic eosinophilic or basophilic nuclei) areoften seen. They are sometimes conspicuous and easy to recognize,thus serving as a clue to the diagnosis. Our objective was to studycases of cutaneous Hodgkin lymphoma to identify the occurrence ofmummified cells. We studied 12 patients (4 women and 8 men; agerange 23-80 years). In 6 patients, cutaneous and extracutaneous dis-ease was identified almost simultaneously; in 4 patients, lymph nodedisease preceded cutaneous involvement; and in the remaining 2 pa-tients, the skin lesions were the presenting sign, whereas lymph nodeinvolvement occurred later. Histopathological, immunohistochemical,and molecular-genetic studies, including rearrangements for TCR, IgHgenes, and PCR for EBV, were performed. Cutaneous biopsy speci-mens revealed either a multinodular or diffuse infiltrate, includedsmall lymphocytes, eosinophils, plasma cells, and macrophages, butin all cases, diagnostic Reed-Sternberg cells and its variants wereidentified. Mummified cells were detected in 9 cases, either as occa-sional scattered mummified cells often requiring a search (6 cases) orbeing conspicuous, grouped and therefore easily identified (3 cases).Immunohistochemically, in all 7 cases studied, mummified cells werepositive for both CD30 and CD15. It is concluded that mummifiedcells are encountered in a majority of cases of cutaneous Hodgkinlymphoma.

Název v anglickém jazyce

Mummified cells are a common finding in cutaneous Hodgkin lymphoma and can be used as a diagnostic clue

Popis výsledku anglicky

Specific cutaneous involvement in Hodgkin lymphoma israre. In cutaneous lesions, the diagnosis is usually based on therecognition of diagnostic Reed-Sternberg cells and its variants. Innodal Hodgkin lymphoma, so-called mummified cells (cells with con-densed cytoplasm and pyknotic eosinophilic or basophilic nuclei) areoften seen. They are sometimes conspicuous and easy to recognize,thus serving as a clue to the diagnosis. Our objective was to studycases of cutaneous Hodgkin lymphoma to identify the occurrence ofmummified cells. We studied 12 patients (4 women and 8 men; agerange 23-80 years). In 6 patients, cutaneous and extracutaneous dis-ease was identified almost simultaneously; in 4 patients, lymph nodedisease preceded cutaneous involvement; and in the remaining 2 pa-tients, the skin lesions were the presenting sign, whereas lymph nodeinvolvement occurred later. Histopathological, immunohistochemical,and molecular-genetic studies, including rearrangements for TCR, IgHgenes, and PCR for EBV, were performed. Cutaneous biopsy speci-mens revealed either a multinodular or diffuse infiltrate, includedsmall lymphocytes, eosinophils, plasma cells, and macrophages, butin all cases, diagnostic Reed-Sternberg cells and its variants wereidentified. Mummified cells were detected in 9 cases, either as occa-sional scattered mummified cells often requiring a search (6 cases) orbeing conspicuous, grouped and therefore easily identified (3 cases).Immunohistochemically, in all 7 cases studied, mummified cells werepositive for both CD30 and CD15. It is concluded that mummifiedcells are encountered in a majority of cases of cutaneous Hodgkinlymphoma.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30109 - Pathology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

The American Journal of Dermatopathology

ISSN

0193-1091

e-ISSN

—

Svazek periodika

42

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

24-28

Kód UT WoS článku

000524344700011

EID výsledku v databázi Scopus

2-s2.0-85077294845