Identification of novel loci and new risk variant in known loci for colorectal cancer risk in East Asians

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10402460" target="_blank" >RIV/00216208:11110/20:10402460 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/20:00539190 RIV/00216208:11140/20:10402460

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Es_.3cB6sC" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Es_.3cB6sC</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1158/1055-9965.EPI-19-0755" target="_blank" >10.1158/1055-9965.EPI-19-0755</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Identification of novel loci and new risk variant in known loci for colorectal cancer risk in East Asians

Popis výsledku v původním jazyce

BACKGROUND: Risk variants identified so far for colorectal cancer (CRC) explain only a small proportion of familial risk of this cancer, particularly in Asians. METHODS: We performed a genome-wide association study (GWAS) of CRC in East Asians including 23,572 CRC cases and 48,700 controls. To identify novel risk loci, we selected sixty promising risk variants for replication using data from 58,131 CRC cases and 67,347 controls of European descent. To identify additional risk variants in known CRC loci, we performed conditional analyses in East Asians. RESULTS: An indel variant, rs67052019 at 1p13.3, was found to be associated with CRC risk at P=3.9 x 10-8 in Asians (OR per allele deletion=1.13, 95%CI=1.08-1.18). This association was replicated in European descendants using a variant (rs2938616) in complete linkage disequilibrium with rs67052019 (P=7.7 x 10-3). Of the remaining 59 variants, 12 showed an association at P&lt;0.05 in the European-ancestry study, including rs11108175 and rs9634162 at P&lt;5x10-8 and two variants with an association near the genome-wide significance level (rs60911071, P=5.8x10-8; rs62558833, P=7.5x10-8) in the combined analyses of Asian- and European-ancestry data. In addition, using data from East Asians, we identified 13 new risk variants at 11 loci reported from previous GWAS. CONCLUSIONS: In this large GWAS, we identified three novel risk loci and two highly suggestive loci for CRC risk and provided evidence for potential roles of multiple genes and pathways in the etiology of CRC. IMPACT: Our study provides novel data to improve the understanding of the genetic basis for CRC risk.

Název v anglickém jazyce

Identification of novel loci and new risk variant in known loci for colorectal cancer risk in East Asians

Popis výsledku anglicky

BACKGROUND: Risk variants identified so far for colorectal cancer (CRC) explain only a small proportion of familial risk of this cancer, particularly in Asians. METHODS: We performed a genome-wide association study (GWAS) of CRC in East Asians including 23,572 CRC cases and 48,700 controls. To identify novel risk loci, we selected sixty promising risk variants for replication using data from 58,131 CRC cases and 67,347 controls of European descent. To identify additional risk variants in known CRC loci, we performed conditional analyses in East Asians. RESULTS: An indel variant, rs67052019 at 1p13.3, was found to be associated with CRC risk at P=3.9 x 10-8 in Asians (OR per allele deletion=1.13, 95%CI=1.08-1.18). This association was replicated in European descendants using a variant (rs2938616) in complete linkage disequilibrium with rs67052019 (P=7.7 x 10-3). Of the remaining 59 variants, 12 showed an association at P&lt;0.05 in the European-ancestry study, including rs11108175 and rs9634162 at P&lt;5x10-8 and two variants with an association near the genome-wide significance level (rs60911071, P=5.8x10-8; rs62558833, P=7.5x10-8) in the combined analyses of Asian- and European-ancestry data. In addition, using data from East Asians, we identified 13 new risk variants at 11 loci reported from previous GWAS. CONCLUSIONS: In this large GWAS, we identified three novel risk loci and two highly suggestive loci for CRC risk and provided evidence for potential roles of multiple genes and pathways in the etiology of CRC. IMPACT: Our study provides novel data to improve the understanding of the genetic basis for CRC risk.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10600 - Biological sciences

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cancer Epidemiology, Biomarkers &amp; Prevention

ISSN

1055-9965

e-ISSN

—

Svazek periodika

29

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

477-486

Kód UT WoS článku

000521285500025

EID výsledku v databázi Scopus

2-s2.0-85079075708