Left ventricular apical pacing in children: feasibility and long-term effect on ventricular function

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10410823" target="_blank" >RIV/00216208:11110/20:10410823 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/20:10410823 RIV/00064203:_____/20:10410823

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=91xcPk5J4C" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=91xcPk5J4C</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/europace/euz325" target="_blank" >10.1093/europace/euz325</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Left ventricular apical pacing in children: feasibility and long-term effect on ventricular function

Popis výsledku v původním jazyce

Aims Left ventricular apical pacing (LVAP) has been reported to preserve left ventricular (LV) function in chronically paced children with complete atrioventricular block (CAVB). We sought to evaluate long-term feasibility of LVAP and the effect on LV mechanics and exercise capacity as compared to normal controls. Methods and results Thirty-six consecutive paediatric patients with CAVB and LVAP in the absence (N=22) or presence of repaired structural heart disease (N=14, systemic LV in all) and 25 age-matched normal controls were cross-sectionally studied after a median of 3.9 (interquartile range 2.1-6.8) years of pacing using echocardiography and exercise stress testing. Pacemaker implantation was uneventful and there was no death. Probability of the absence of pacemaker-related surgical revision (elective generator replacement excluded) was 89.0% at 5years after implantation. Left ventricular apical pacing patients had lower maximum oxygen uptake (P=0.009), no septal to lateral but significant apical to basal LV mechanical delay (P&lt;0.001) which correlated with decreased LV contraction efficiency (P=0.001). Left ventricular ejection fraction and global longitudinal LV strain were, however, not different from controls. Results were similar in both the presence and absence of structural heart disease. Conclusion Left ventricular apical pacing is technically feasible with a low reintervention rate. Mechanical synchrony between LV septum and free wall is maintained at the price of an apical to basal mechanical delay associated with LV contraction inefficiency as compared to healthy controls. Global LV systolic function is, however, not negatively affected by LVAP.

Název v anglickém jazyce

Left ventricular apical pacing in children: feasibility and long-term effect on ventricular function

Popis výsledku anglicky

Aims Left ventricular apical pacing (LVAP) has been reported to preserve left ventricular (LV) function in chronically paced children with complete atrioventricular block (CAVB). We sought to evaluate long-term feasibility of LVAP and the effect on LV mechanics and exercise capacity as compared to normal controls. Methods and results Thirty-six consecutive paediatric patients with CAVB and LVAP in the absence (N=22) or presence of repaired structural heart disease (N=14, systemic LV in all) and 25 age-matched normal controls were cross-sectionally studied after a median of 3.9 (interquartile range 2.1-6.8) years of pacing using echocardiography and exercise stress testing. Pacemaker implantation was uneventful and there was no death. Probability of the absence of pacemaker-related surgical revision (elective generator replacement excluded) was 89.0% at 5years after implantation. Left ventricular apical pacing patients had lower maximum oxygen uptake (P=0.009), no septal to lateral but significant apical to basal LV mechanical delay (P&lt;0.001) which correlated with decreased LV contraction efficiency (P=0.001). Left ventricular ejection fraction and global longitudinal LV strain were, however, not different from controls. Results were similar in both the presence and absence of structural heart disease. Conclusion Left ventricular apical pacing is technically feasible with a low reintervention rate. Mechanical synchrony between LV septum and free wall is maintained at the price of an apical to basal mechanical delay associated with LV contraction inefficiency as compared to healthy controls. Global LV systolic function is, however, not negatively affected by LVAP.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Europace

ISSN

1099-5129

e-ISSN

—

Svazek periodika

22

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

306-313

Kód UT WoS článku

000515102900025

EID výsledku v databázi Scopus

2-s2.0-85079098092