Methylene blue administration in patients with refractory distributive shock - a retrospective study
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10413913" target="_blank" >RIV/00216208:11110/20:10413913 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00064165:_____/20:10413913
Výsledek na webu
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=WR-TzgjXrJ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=WR-TzgjXrJ</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-020-58828-4" target="_blank" >10.1038/s41598-020-58828-4</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Methylene blue administration in patients with refractory distributive shock - a retrospective study
Popis výsledku v původním jazyce
Hemodynamic effectiveness of methylene blue (MB) was tested in patients with refractory distributive shock. A retrospective analysis of 20 critically-ill patients who developed refractory shock was performed. Patients were divided into two study groups as responders with positive hemodynamic response to MB administration (defined as 10% decrease of norepinephrine dose) and non-responders. Hemodynamic, outcome data and baseline tissue hypoxia-related parameters including ratio of central venous-to-arterial carbon dioxide tension to arterio-venous oxygen content (P(v-a)CO2/C(a-v)O-2) were compared between the groups. There were 9 (45%) responders and 11 (55%) non-responders to single bolus of MB administration. Dose of MB did not differ between responders and non-responders (1.3 +/- 0.5 vs. 1.3 +/- 0.4mg/kg respectively, P=0.979). MB responders had lower baseline P(v-a) CO2/C(a-v)O-2 (1.79 +/- 0.73 vs. 3.24 +/- 1.18, P=0.007), higher pH (7.26 +/- 0.11 vs. 7.16 +/- 0.10, P=0.037) and lower lactate levels at 12hours post MB administration (3.4 +/- 2.7 vs. 9.9 +/- 2.2mmol/L, P=0.002) compared to non-responders. Methylene blue represents a non-adrenergic vasopressor with only limited effectiveness in patients with refractory distributive shock. Profound tissue hypoxia with high degree of anaerobic metabolism was associated with the loss of hemodynamic responsiveness to its administration.
Název v anglickém jazyce
Methylene blue administration in patients with refractory distributive shock - a retrospective study
Popis výsledku anglicky
Hemodynamic effectiveness of methylene blue (MB) was tested in patients with refractory distributive shock. A retrospective analysis of 20 critically-ill patients who developed refractory shock was performed. Patients were divided into two study groups as responders with positive hemodynamic response to MB administration (defined as 10% decrease of norepinephrine dose) and non-responders. Hemodynamic, outcome data and baseline tissue hypoxia-related parameters including ratio of central venous-to-arterial carbon dioxide tension to arterio-venous oxygen content (P(v-a)CO2/C(a-v)O-2) were compared between the groups. There were 9 (45%) responders and 11 (55%) non-responders to single bolus of MB administration. Dose of MB did not differ between responders and non-responders (1.3 +/- 0.5 vs. 1.3 +/- 0.4mg/kg respectively, P=0.979). MB responders had lower baseline P(v-a) CO2/C(a-v)O-2 (1.79 +/- 0.73 vs. 3.24 +/- 1.18, P=0.007), higher pH (7.26 +/- 0.11 vs. 7.16 +/- 0.10, P=0.037) and lower lactate levels at 12hours post MB administration (3.4 +/- 2.7 vs. 9.9 +/- 2.2mmol/L, P=0.002) compared to non-responders. Methylene blue represents a non-adrenergic vasopressor with only limited effectiveness in patients with refractory distributive shock. Profound tissue hypoxia with high degree of anaerobic metabolism was associated with the loss of hemodynamic responsiveness to its administration.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30223 - Anaesthesiology
Návaznosti výsledku
Projekt
—
Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Scientific Reports
ISSN
2045-2322
e-ISSN
—
Svazek periodika
10
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
8
Strana od-do
1828
Kód UT WoS článku
000559933700001
EID výsledku v databázi Scopus
2-s2.0-85078987294