Preoperative prostate health index predicts adverse pathology and Gleason score upgrading after radical prostatectomy for prostate cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10415027" target="_blank" >RIV/00216208:11110/20:10415027 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/20:43920573 RIV/00216208:11130/20:10415027 RIV/00216208:11140/20:10415027 RIV/00669806:_____/20:10415027 a 3 dalších

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ovPOo..HEJ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ovPOo..HEJ</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12894-020-00711-5" target="_blank" >10.1186/s12894-020-00711-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Preoperative prostate health index predicts adverse pathology and Gleason score upgrading after radical prostatectomy for prostate cancer

Popis výsledku v původním jazyce

BACKGROUND: We aimed to explore the utility of prostate specific antigen (PSA) isoform [- 2] proPSA and its derivatives for prediction of pathological outcome after radical prostatectomy (RP). METHODS: Preoperative blood samples were prospectively and consecutivelyanalyzed from 472 patients treated with RP for clinically localized prostate cancerat four medical centers. Measured parameters were PSA, free PSA (fPSA), fPSA/PSA ratio, [- 2] proPSA (p2PSA), p2PSA/fPSA ratio and Prostate Health Index (PHI)(p2PSA/fPSA)*SQUARE ROOTPSA]. Logistic regression models were fitted to determine the accuracy of markers for prediction of pathological Gleason score (GS) &gt;=7, Gleason score upgrading, extracapsular extension of the tumor (pT3) and the presence of positive surgical margin (PSM). The accuracy of predictive models was compared using area under the receiver operating curve (AUC). RESULTS: Of 472 patients undergoing RP, 339 (72%) were found to have pathologic GS &gt;= 7, out of them 178 (53%) experienced an upgrade from their preoperative GS = 6. The findings of pT3 and PSM were present in 132 (28%) and 133 (28%) cases, respectively. At univariable analysis of all the preoperative parameters, PHI was the most accurate predictor of pathological GS &gt;=7 (OR 1.02, 95% CI 1.01-1.03, p&lt;0.001), GS upgrading (OR 1.02, 95% CI 1.01-1.03, p&lt;0.003), pT3 disease (OR 1.01, 95% CI 1.00-1.02, p&lt;0.007) and the presence of PSM (OR 1.01, 95% CI 1.00-1.02, p&lt;0.002). Adding of PHI into the base multivariable model increased significantly the accuracy for prediction of pathological GS by 4.4% to AUC = 66.6 (p = 0.015) and GS upgrading by 5.0% to AUC = 65.9 (p = 0.025), respectively. CONCLUSIONS: Preoperative PHI levels may contribute significantly to prediction of prostate cancer aggressiveness and expansion of the tumor detected at final pathology.

Název v anglickém jazyce

Preoperative prostate health index predicts adverse pathology and Gleason score upgrading after radical prostatectomy for prostate cancer

Popis výsledku anglicky

BACKGROUND: We aimed to explore the utility of prostate specific antigen (PSA) isoform [- 2] proPSA and its derivatives for prediction of pathological outcome after radical prostatectomy (RP). METHODS: Preoperative blood samples were prospectively and consecutivelyanalyzed from 472 patients treated with RP for clinically localized prostate cancerat four medical centers. Measured parameters were PSA, free PSA (fPSA), fPSA/PSA ratio, [- 2] proPSA (p2PSA), p2PSA/fPSA ratio and Prostate Health Index (PHI)(p2PSA/fPSA)*SQUARE ROOTPSA]. Logistic regression models were fitted to determine the accuracy of markers for prediction of pathological Gleason score (GS) &gt;=7, Gleason score upgrading, extracapsular extension of the tumor (pT3) and the presence of positive surgical margin (PSM). The accuracy of predictive models was compared using area under the receiver operating curve (AUC). RESULTS: Of 472 patients undergoing RP, 339 (72%) were found to have pathologic GS &gt;= 7, out of them 178 (53%) experienced an upgrade from their preoperative GS = 6. The findings of pT3 and PSM were present in 132 (28%) and 133 (28%) cases, respectively. At univariable analysis of all the preoperative parameters, PHI was the most accurate predictor of pathological GS &gt;=7 (OR 1.02, 95% CI 1.01-1.03, p&lt;0.001), GS upgrading (OR 1.02, 95% CI 1.01-1.03, p&lt;0.003), pT3 disease (OR 1.01, 95% CI 1.00-1.02, p&lt;0.007) and the presence of PSM (OR 1.01, 95% CI 1.00-1.02, p&lt;0.002). Adding of PHI into the base multivariable model increased significantly the accuracy for prediction of pathological GS by 4.4% to AUC = 66.6 (p = 0.015) and GS upgrading by 5.0% to AUC = 65.9 (p = 0.025), respectively. CONCLUSIONS: Preoperative PHI levels may contribute significantly to prediction of prostate cancer aggressiveness and expansion of the tumor detected at final pathology.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30217 - Urology and nephrology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BMC Urology

ISSN

1471-2490

e-ISSN

—

Svazek periodika

20

Číslo periodika v rámci svazku

September

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

144

Kód UT WoS článku

000571052500001

EID výsledku v databázi Scopus

2-s2.0-85090504926