Pre-school and school-aged children benefit from the switch from a sensor-augmented pump to an AndroidAPS hybrid closed loop: A retrospective analysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F21%3A10423103" target="_blank" >RIV/00216208:11110/21:10423103 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/21:10423103 RIV/00216208:11130/21:10423103

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=aN9hO--HE9" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=aN9hO--HE9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/pedi.13190" target="_blank" >10.1111/pedi.13190</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Pre-school and school-aged children benefit from the switch from a sensor-augmented pump to an AndroidAPS hybrid closed loop: A retrospective analysis

Popis výsledku v původním jazyce

Data on closed loop systems in young children with type 1 diabetes (T1D) are limited. We tested the efficacy and safety of an open-source, do-it-yourself automated insulin delivery system AndroidAPS in preschool and school-aged children. Research Design and Methods: This retrospective study analyzed diabetes control in 18 preschool (3-7 years) and 18 school-aged children (8-14 years) with T1D who switched from a sensor-augmented pump (SAP) to AndroidAPS. We compared the CGM parameters and HbA1c levels 3 months before and 6 months after the initiation of AndroidAPS therapy and evaluated frequency of severe adverse events during AndroidAPS use, the most frequent reasons for its interruption, and the experience and psychosocial benefits of AndroidAPS use. General glycemic control was significantly improved after the switch from SAP to AndroidAPS. Time in range (TIR) increased in both preschool (70.8 to 78.6%, p = 0.004) and school-aged children (77.2 to 82.9%, p &lt; 0.001), whereas HbA1c levels decreased (preschool children 53.8 to 48.5 mmol/mol, p &lt; 0.001; school-aged children 52.6 to 45.1 mmol/mol, p = 0.001). Time spent in range of 3.0-3.8 mmol/L increased slightly in school children (2.6 to 3.8%, p = 0.040), but not in preschool children (3.0 to 3.0%, p = 0.913). Time spent at &lt;3 mmol/L remained unchanged in both preschool (0.95 to 0.67%, p = 0.432) and school-aged children (0.8 to 0.8%, p = 1.000). No episodes of severe hypoglycemia or DKA and significant improvement of quality of life were reported by AndroidAPS users. AndroidAPS seems effective for T1D control both in preschool and school-age children but further validation by prospective studies is necessary.

Název v anglickém jazyce

Pre-school and school-aged children benefit from the switch from a sensor-augmented pump to an AndroidAPS hybrid closed loop: A retrospective analysis

Popis výsledku anglicky

Data on closed loop systems in young children with type 1 diabetes (T1D) are limited. We tested the efficacy and safety of an open-source, do-it-yourself automated insulin delivery system AndroidAPS in preschool and school-aged children. Research Design and Methods: This retrospective study analyzed diabetes control in 18 preschool (3-7 years) and 18 school-aged children (8-14 years) with T1D who switched from a sensor-augmented pump (SAP) to AndroidAPS. We compared the CGM parameters and HbA1c levels 3 months before and 6 months after the initiation of AndroidAPS therapy and evaluated frequency of severe adverse events during AndroidAPS use, the most frequent reasons for its interruption, and the experience and psychosocial benefits of AndroidAPS use. General glycemic control was significantly improved after the switch from SAP to AndroidAPS. Time in range (TIR) increased in both preschool (70.8 to 78.6%, p = 0.004) and school-aged children (77.2 to 82.9%, p &lt; 0.001), whereas HbA1c levels decreased (preschool children 53.8 to 48.5 mmol/mol, p &lt; 0.001; school-aged children 52.6 to 45.1 mmol/mol, p = 0.001). Time spent in range of 3.0-3.8 mmol/L increased slightly in school children (2.6 to 3.8%, p = 0.040), but not in preschool children (3.0 to 3.0%, p = 0.913). Time spent at &lt;3 mmol/L remained unchanged in both preschool (0.95 to 0.67%, p = 0.432) and school-aged children (0.8 to 0.8%, p = 1.000). No episodes of severe hypoglycemia or DKA and significant improvement of quality of life were reported by AndroidAPS users. AndroidAPS seems effective for T1D control both in preschool and school-age children but further validation by prospective studies is necessary.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pediatric Diabetes

ISSN

1399-543X

e-ISSN

—

Svazek periodika

22

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

594-604

Kód UT WoS článku

000621585600001

EID výsledku v databázi Scopus

2-s2.0-85101645931