Tumor control and trigeminal dysfunction improvement after stereotactic radiosurgery for trigeminal schwannomas: a systematic review and meta-analysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F21%3A10423190" target="_blank" >RIV/00216208:11110/21:10423190 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61383082:_____/21:00001026

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=8tbFHFhdj0" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=8tbFHFhdj0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10143-020-01433-w" target="_blank" >10.1007/s10143-020-01433-w</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Tumor control and trigeminal dysfunction improvement after stereotactic radiosurgery for trigeminal schwannomas: a systematic review and meta-analysis

Popis výsledku v původním jazyce

Trigeminal nerve schwannomas (TS) are uncommon intracranial tumors, frequently presenting with debilitating trigeminal and/or oculomotor nerve dysfunction. While surgical resection has been described, its morbidity and mortality rates are non-negligible. Stereotactic radiosurgery (SRS) has emerged with variable results as a valuable alternative. Here, we aimed at reviewing the medical literature on TS treated with SRS so as to investigate rates of tumor control and symptomatic improvement. We reviewed manuscripts published between January 1990 and December 2019 on PubMed. Tumor control and symptomatic improvement rates were evaluated with separate meta-analyses. This meta-analysis included 18 studies comprising a total of 564 patients. Among them, only one reported the outcomes of linear accelerators (Linac), while the others of GK. Tumor control rates after SRS were 92.3% (range 90.1-94.5; p &lt; 0.001), and tumor decrease rates were 62.7% (range 54.3-71, p &lt; 0.001). Tumor progression rates were 9.4% (range 6.8-11.9, p &lt; 0.001). Clinical improvement rates of trigeminal neuralgia were 63.5% (52.9-74.1, p &lt; 0.001) and of oculomotor nerves were 48.2% (range 36-60.5, p &lt; 0.001). Clinical worsening rate was 10.7% (range 7.6-13.8, p &lt; 0.001). Stereotactic radiosurgery for TS is associated with high tumor control rates and favorable clinical outcomes, especially for trigeminal neuralgia and oculomotor nerves. However, patients should be correctly advised about the risk of tumor progression and potential clinical worsening. Future clinical studies should focus on standard reporting of clinical outcomes.

Název v anglickém jazyce

Tumor control and trigeminal dysfunction improvement after stereotactic radiosurgery for trigeminal schwannomas: a systematic review and meta-analysis

Popis výsledku anglicky

Trigeminal nerve schwannomas (TS) are uncommon intracranial tumors, frequently presenting with debilitating trigeminal and/or oculomotor nerve dysfunction. While surgical resection has been described, its morbidity and mortality rates are non-negligible. Stereotactic radiosurgery (SRS) has emerged with variable results as a valuable alternative. Here, we aimed at reviewing the medical literature on TS treated with SRS so as to investigate rates of tumor control and symptomatic improvement. We reviewed manuscripts published between January 1990 and December 2019 on PubMed. Tumor control and symptomatic improvement rates were evaluated with separate meta-analyses. This meta-analysis included 18 studies comprising a total of 564 patients. Among them, only one reported the outcomes of linear accelerators (Linac), while the others of GK. Tumor control rates after SRS were 92.3% (range 90.1-94.5; p &lt; 0.001), and tumor decrease rates were 62.7% (range 54.3-71, p &lt; 0.001). Tumor progression rates were 9.4% (range 6.8-11.9, p &lt; 0.001). Clinical improvement rates of trigeminal neuralgia were 63.5% (52.9-74.1, p &lt; 0.001) and of oculomotor nerves were 48.2% (range 36-60.5, p &lt; 0.001). Clinical worsening rate was 10.7% (range 7.6-13.8, p &lt; 0.001). Stereotactic radiosurgery for TS is associated with high tumor control rates and favorable clinical outcomes, especially for trigeminal neuralgia and oculomotor nerves. However, patients should be correctly advised about the risk of tumor progression and potential clinical worsening. Future clinical studies should focus on standard reporting of clinical outcomes.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neurosurgical Review

ISSN

0344-5607

e-ISSN

—

Svazek periodika

44

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

13

Strana od-do

2391-2403

Kód UT WoS článku

000589482200001

EID výsledku v databázi Scopus

2-s2.0-85096014791